Atomistry » Zinc » PDB 6fgs-6frz » 6fpu
Atomistry »
  Zinc »
    PDB 6fgs-6frz »
      6fpu »

Zinc in PDB 6fpu: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6fpu was solved by A.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.23 / 1.36
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 88.623, 64.690, 70.502, 90.00, 93.49, 90.00
R / Rfree (%) 12.8 / 15.4

Other elements in 6fpu:

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One (pdb code 6fpu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6fpu:

Zinc binding site 1 out of 1 in 6fpu

Go back to Zinc Binding Sites List in 6fpu
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:13.7
occ:0.81
 ND1 A:HIS349 2.2 14.7 1.0
SG A:CYS323 2.3 16.3 1.0
SG A:CYS320 2.3 15.6 1.0
SG A:CYS318 2.3 18.0 1.0
CE1 A:HIS349 3.0 15.5 1.0
HB3 A:CYS318 3.0 22.8 1.0
HB2 A:CYS323 3.0 20.1 1.0
HE1 A:HIS349 3.0 18.6 1.0
HB3 A:CYS320 3.1 18.5 1.0
CB A:CYS318 3.2 19.0 1.0
CB A:CYS323 3.3 16.8 1.0
CG A:HIS349 3.3 13.6 1.0
H A:CYS323 3.3 18.6 1.0
CB A:CYS320 3.3 15.4 1.0
HB2 A:HIS349 3.4 16.0 1.0
H A:CYS320 3.4 21.1 1.0
HA A:HIS349 3.5 14.7 1.0
HB2 A:CYS318 3.6 22.8 1.0
CB A:HIS349 3.7 13.4 1.0
HB A:VAL322 3.8 17.9 1.0
N A:CYS323 3.9 15.5 1.0
HB3 A:CYS323 4.0 20.1 1.0
N A:CYS320 4.1 17.6 1.0
HB2 A:CYS320 4.1 18.5 1.0
CA A:HIS349 4.1 12.3 1.0
HB2 A:LEU314 4.2 19.4 1.0
NE2 A:HIS349 4.2 15.6 1.0
CA A:CYS323 4.2 16.5 1.0
CA A:CYS320 4.2 16.5 1.0
CD2 A:HIS349 4.3 13.8 1.0
HB3 A:ALA352 4.4 15.4 1.0
HE22 A:GLN356 4.4 27.7 1.0
HB3 A:ASP315 4.5 23.3 1.0
HD12 A:LEU314 4.5 19.2 1.0
H A:ASP315 4.5 20.6 1.0
CA A:CYS318 4.5 20.3 1.0
O A:HIS349 4.6 12.6 1.0
HA A:CYS323 4.6 19.8 1.0
HB3 A:HIS349 4.7 16.0 1.0
C A:CYS320 4.7 16.4 1.0
O A:CYS320 4.7 16.9 1.0
C A:CYS318 4.7 20.8 1.0
H A:VAL322 4.8 18.6 1.0
CB A:VAL322 4.8 14.9 1.0
C A:HIS349 4.8 11.9 1.0
O A:CYS318 4.8 21.5 1.0
HE2 A:HIS349 4.9 18.7 1.0
C A:VAL322 4.9 15.8 1.0
HA A:CYS318 5.0 24.4 1.0

Reference:

L.D.Movsisyan, E.Schafer, A.Nguyen, F.R.Ehrmann, A.Schwab, T.Rossolini, D.Zimmerli, B.Wagner, H.Daff, A.Heine, G.Klebe, F.Diederich. Sugar Acetonides Are A Superior Motif For Addressing the Large, Solvent-Exposed Ribose-33 Pocket of Trna-Guanine Transglycosylase. Chemistry V. 24 9957 2018.
ISSN: ISSN 1521-3765
PubMed: 29939431
DOI: 10.1002/CHEM.201801756
Page generated: Mon Oct 28 21:17:26 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy