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Zinc in PDB 6fmn: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-OneEnzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29; Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6fmn
was solved by
A.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6fmn:
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
(pdb code 6fmn). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6fmn: Zinc binding site 1 out of 1 in 6fmnGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((2R,3S,4R,5R)-3,4-Dihydroxy-5-Methoxytetrahydrofuran-2- Yl)Methyl)Amino)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One
![]() Mono view ![]() Stereo pair view
Reference:
L.D.Movsisyan,
E.Schafer,
A.Nguyen,
F.R.Ehrmann,
A.Schwab,
T.Rossolini,
D.Zimmerli,
B.Wagner,
H.Daff,
A.Heine,
G.Klebe,
F.Diederich.
Sugar Acetonides Are A Superior Motif For Addressing the Large, Solvent-Exposed Ribose-33 Pocket of Trna-Guanine Transglycosylase. Chemistry V. 24 9957 2018.
Page generated: Wed Dec 16 11:48:45 2020
ISSN: ISSN 1521-3765 PubMed: 29939431 DOI: 10.1002/CHEM.201801756 |
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