Zinc in PDB 6fgs: Solution Structure of P300TAZ2-P73TA1

All present enzymatic activity of Solution Structure of P300TAZ2-P73TA1:
2.3.1.48;

The binding sites of Zinc atom in the Solution Structure of P300TAZ2-P73TA1 (pdb code 6fgs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Solution Structure of P300TAZ2-P73TA1, PDB code: 6fgs:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Solution Structure of P300TAZ2-P73TA1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of P300TAZ2-P73TA1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:0.0 occ:1.00 NE2 A:HIS22 2.0 0.0 1.0 SG A:CYS26 2.2 0.0 1.0 SG A:CYS31 2.2 0.0 1.0 SG A:CYS36 2.3 0.0 1.0 HB2 A:CYS26 2.9 0.0 1.0 CB A:CYS26 2.9 0.0 1.0 CD2 A:HIS22 2.9 0.0 1.0 HB3 A:CYS31 3.0 0.0 1.0 CB A:CYS31 3.1 0.0 1.0 CE1 A:HIS22 3.1 0.0 1.0 HD2 A:HIS22 3.1 0.0 1.0 HB3 A:CYS26 3.1 0.0 1.0 HB2 A:CYS31 3.4 0.0 1.0 HE1 A:HIS22 3.4 0.0 1.0 CB A:CYS36 3.7 0.0 1.0 HB2 A:CYS36 3.7 0.0 1.0 HB3 A:CYS36 4.0 0.0 1.0 CG A:HIS22 4.1 0.0 1.0 HA A:ALA23 4.2 0.0 1.0 ND1 A:HIS22 4.2 0.0 1.0 HE3 A:LYS40 4.2 0.0 1.0 CA A:CYS26 4.4 0.0 1.0 CA A:CYS31 4.5 0.0 1.0 HA A:CYS26 4.6 0.0 1.0 HD11 A:LEU33 4.6 0.0 1.0 HE2 A:LYS40 4.6 0.0 1.0 C A:CYS31 4.8 0.0 1.0 HB2 A:ASN28 4.8 0.0 1.0 HA A:CYS31 4.9 0.0 1.0 CA A:CYS36 4.9 0.0 1.0 CE A:LYS40 5.0 0.0 1.0 H A:ASN28 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the Solution Structure of P300TAZ2-P73TA1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of P300TAZ2-P73TA1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:0.0 occ:1.00 NE2 A:HIS45 2.2 0.0 1.0 SG A:CYS57 2.3 0.0 1.0 SG A:CYS60 2.4 0.0 1.0 SG A:CYS49 2.4 0.0 1.0 HB3 A:CYS57 3.0 0.0 1.0 CD2 A:HIS45 3.0 0.0 1.0 H A:CYS57 3.1 0.0 1.0 CE1 A:HIS45 3.1 0.0 1.0 HD2 A:HIS45 3.2 0.0 1.0 CB A:CYS57 3.3 0.0 1.0 HE1 A:HIS45 3.4 0.0 1.0 H A:CYS60 3.6 0.0 1.0 HB3 A:CYS49 3.6 0.0 1.0 CB A:CYS49 3.7 0.0 1.0 HB A:ILE59 3.9 0.0 1.0 N A:CYS57 3.9 0.0 1.0 CB A:CYS60 4.1 0.0 1.0 HB2 A:CYS57 4.1 0.0 1.0 CG A:HIS45 4.1 0.0 1.0 CA A:CYS57 4.1 0.0 1.0 ND1 A:HIS45 4.2 0.0 1.0 HG23 A:THR46 4.2 0.0 1.0 N A:CYS60 4.3 0.0 1.0 HB2 A:CYS49 4.4 0.0 1.0 HA A:THR46 4.4 0.0 1.0 HB2 A:CYS60 4.5 0.0 1.0 CA A:CYS60 4.6 0.0 1.0 HA A:CYS60 4.6 0.0 1.0 HA A:CYS49 4.6 0.0 1.0 HB3 A:CYS60 4.8 0.0 1.0 C A:CYS57 4.8 0.0 1.0 CA A:CYS49 4.8 0.0 1.0 HD3 A:ARG51 4.9 0.0 1.0 HG2 A:LYS52 4.9 0.0 1.0 H A:ILE59 4.9 0.0 1.0 HA2 A:GLY56 5.0 0.0 1.0 O A:CYS57 5.0 0.0 1.0 CB A:ILE59 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the Solution Structure of P300TAZ2-P73TA1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Solution Structure of P300TAZ2-P73TA1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn203 b:0.0 occ:1.00 NE2 A:HIS70 2.2 0.0 1.0 SG A:CYS74 2.3 0.0 1.0 SG A:CYS79 2.3 0.0 1.0 HB2 A:CYS74 2.4 0.0 1.0 SG A:CYS84 2.4 0.0 1.0 CB A:CYS74 2.6 0.0 1.0 HB3 A:CYS79 2.7 0.0 1.0 HB3 A:CYS74 2.8 0.0 1.0 CB A:CYS79 3.0 0.0 1.0 CE1 A:HIS70 3.0 0.0 1.0 CD2 A:HIS70 3.1 0.0 1.0 HE1 A:HIS70 3.3 0.0 1.0 HD2 A:HIS70 3.4 0.0 1.0 CB A:CYS84 3.6 0.0 1.0 HB3 A:CYS84 3.6 0.0 1.0 HA A:CYS79 3.7 0.0 1.0 HA A:ALA71 3.8 0.0 1.0 HB2 A:CYS84 3.8 0.0 1.0 HB2 A:CYS79 3.8 0.0 1.0 CA A:CYS79 4.0 0.0 1.0 ND1 A:HIS70 4.1 0.0 1.0 CA A:CYS74 4.1 0.0 1.0 CG A:HIS70 4.1 0.0 1.0 HD2 A:PRO80 4.2 0.0 1.0 HA A:CYS74 4.4 0.0 1.0 O A:HIS70 4.4 0.0 1.0 HB A:VAL81 4.6 0.0 1.0 H A:CYS74 4.7 0.0 1.0 O A:GLU76 4.8 0.0 1.0 N A:CYS74 4.8 0.0 1.0 CA A:ALA71 4.8 0.0 1.0 C A:HIS70 4.8 0.0 1.0 H A:VAL81 4.8 0.0 1.0 H A:CYS79 4.8 0.0 1.0 HD1 A:HIS70 4.9 0.0 1.0 N A:CYS79 4.9 0.0 1.0 CA A:CYS84 4.9 0.0 1.0 C A:CYS79 5.0 0.0 1.0

K.Krauskopf, J.Gebel, S.Kazemi, M.Tuppi, F.Lohr, B.Schafer, J.Koch, P.Guntert, V.Dotsch, S.Kehrloesser. Regulation of the Activity in the P53 Family Depends on the Organization of the Transactivation Domain. Structure V. 26 1091 2018.
ISSN: ISSN 1878-4186
PubMed: 30099987
DOI: 10.1016/J.STR.2018.05.013