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Zinc in PDB 6ez9: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372
Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372
All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372:
3.4.17.21;
3.4.17.21;
Protein crystallography data
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372, PDB code: 6ez9
was solved by
C.Barinka,
Z.Novakova,
L.Motlova,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 1.61 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 101.742, 130.449, 159.796, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.3 / 18.1 |
Other elements in 6ez9:
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
| Calcium | (Ca) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372
(pdb code 6ez9). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372, PDB code: 6ez9:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372, PDB code: 6ez9:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 6ez9
Go back to
Zinc Binding Sites List in 6ez9
Zinc binding site 1 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372 within 5.0Å range:
|
Zinc binding site 2 out of 2 in 6ez9
Go back to
Zinc Binding Sites List in 6ez9
Zinc binding site 2 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Inhibitor JHU3372 within 5.0Å range:
|
Reference:
C.Barinka,
Z.Novakova,
N.Hin,
D.Bim,
D.V.Ferraris,
B.Duvall,
G.Kabarriti,
R.Tsukamoto,
M.Budesinsky,
L.Motlova,
C.Rojas,
B.S.Slusher,
T.A.Rokob,
L.Rulisek,
T.Tsukamoto.
Structural and Computational Basis For Potent Inhibition of Glutamate Carboxypeptidase II By Carbamate-Based Inhibitors. Bioorg.Med.Chem. V. 27 255 2019.
ISSN: ESSN 1464-3391
PubMed: 30552009
DOI: 10.1016/J.BMC.2018.11.022
Page generated: Mon Oct 28 20:30:59 2024
ISSN: ESSN 1464-3391
PubMed: 30552009
DOI: 10.1016/J.BMC.2018.11.022
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