Zinc in PDB 6evk: Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP

Enzymatic activity of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP

All present enzymatic activity of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP, PDB code: 6evk was solved by A.Pflug, S.Cusack, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.90
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 269.340, 148.700, 88.510, 90.00, 98.17, 90.00
R / Rfree (%) 23.4 / 27.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP (pdb code 6evk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP, PDB code: 6evk:

Zinc binding site 1 out of 1 in 6evk

Go back to Zinc Binding Sites List in 6evk
Zinc binding site 1 out of 1 in the Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Bat Influenza A/H17N10 Polymerase with Viral Rna Promoter and Cap Analogue M7GTP within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn801

b:90.6
occ:1.00
 OD1 A:ASP421 3.4 64.8 1.0
OD2 A:ASP421 3.5 66.2 1.0
ND1 B:HIS562 3.5 81.1 1.0
CG A:ASP421 3.9 65.0 1.0
NZ B:LYS553 4.0 75.7 1.0
CE1 B:HIS562 4.2 85.6 1.0
CD B:LYS553 4.2 67.1 1.0
CE2 B:TYR557 4.2 74.7 1.0
CD B:ARG556 4.4 60.1 1.0
CD2 B:TYR557 4.7 73.8 1.0
CG B:HIS562 4.7 81.5 1.0
CE B:LYS553 4.7 71.2 1.0
CB B:ARG556 4.9 60.2 1.0
NH1 B:ARG556 5.0 64.8 1.0

Reference:

A.Pflug, S.Gaudon, P.Resa-Infante, M.Lethier, S.Reich, W.M.Schulze, S.Cusack. Capped Rna Primer Binding to Influenza Polymerase and Implications For the Mechanism of Cap-Binding Inhibitors. Nucleic Acids Res. V. 46 956 2018.
ISSN: ESSN 1362-4962
PubMed: 29202182
DOI: 10.1093/NAR/GKX1210
Page generated: Wed Dec 16 11:44:51 2020

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