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Zinc in PDB 6esm: Crystal Structure of MMP9 in Complex with Inhibitor BE4.Enzymatic activity of Crystal Structure of MMP9 in Complex with Inhibitor BE4.
All present enzymatic activity of Crystal Structure of MMP9 in Complex with Inhibitor BE4.:
3.4.24.35; Protein crystallography data
The structure of Crystal Structure of MMP9 in Complex with Inhibitor BE4., PDB code: 6esm
was solved by
L.Ciccone,
L.Tepshi,
E.Nuti,
A.Rossello,
E.A.Stura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6esm:
The structure of Crystal Structure of MMP9 in Complex with Inhibitor BE4. also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of MMP9 in Complex with Inhibitor BE4.
(pdb code 6esm). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of MMP9 in Complex with Inhibitor BE4., PDB code: 6esm: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 6esmGo back to Zinc Binding Sites List in 6esm
Zinc binding site 1 out
of 2 in the Crystal Structure of MMP9 in Complex with Inhibitor BE4.
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 6esmGo back to Zinc Binding Sites List in 6esm
Zinc binding site 2 out
of 2 in the Crystal Structure of MMP9 in Complex with Inhibitor BE4.
Mono view Stereo pair view
Reference:
E.Nuti,
D.Cuffaro,
E.Bernardini,
C.Camodeca,
L.Panelli,
S.Chaves,
L.Ciccone,
L.Tepshi,
L.Vera,
E.Orlandini,
S.Nencetti,
E.A.Stura,
M.A.Santos,
V.Dive,
A.Rossello.
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, uc(Nmr), and Crystallographic Studies. J. Med. Chem. V. 61 4421 2018.
Page generated: Wed Dec 16 11:43:54 2020
ISSN: ISSN 1520-4804 PubMed: 29727184 DOI: 10.1021/ACS.JMEDCHEM.8B00096 |
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