Zinc »
PDB 6ee7-6eok »
6en5 »
Zinc in PDB 6en5: Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
Enzymatic activity of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
All present enzymatic activity of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.:
3.4.15.1;
3.4.15.1;
Protein crystallography data
The structure of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor., PDB code: 6en5
was solved by
G.E.Cozier,
K.R.Acharya,
S.Fienberg,
K.Chibale,
E.D.Sturrock,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 79.48 / 1.75 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.167, 103.447, 115.446, 84.86, 85.49, 81.99 |
| R / Rfree (%) | 17.3 / 19.8 |
Other elements in 6en5:
The structure of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor. also contains other interesting chemical elements:
| Magnesium | (Mg) | 4 atoms |
| Chlorine | (Cl) | 4 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
(pdb code 6en5). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor., PDB code: 6en5:
Jump to Zinc binding site number: 1; 2; 3; 4;
In total 4 binding sites of Zinc where determined in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor., PDB code: 6en5:
Jump to Zinc binding site number: 1; 2; 3; 4;
Zinc binding site 1 out of 4 in 6en5
Go back to
Zinc Binding Sites List in 6en5
Zinc binding site 1 out
of 4 in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor. within 5.0Å range:
|
Zinc binding site 2 out of 4 in 6en5
Go back to
Zinc Binding Sites List in 6en5
Zinc binding site 2 out
of 4 in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor. within 5.0Å range:
|
Zinc binding site 3 out of 4 in 6en5
Go back to
Zinc Binding Sites List in 6en5
Zinc binding site 3 out
of 4 in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor. within 5.0Å range:
|
Zinc binding site 4 out of 4 in 6en5
Go back to
Zinc Binding Sites List in 6en5
Zinc binding site 4 out
of 4 in the Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Crystal Structure A of the Angiotensin-1 Converting Enzyme N-Domain in Complex with A Diprolyl Inhibitor. within 5.0Å range:
|
Reference:
S.Fienberg,
G.E.Cozier,
K.R.Acharya,
K.Chibale,
E.D.Sturrock.
The Design and Development of A Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme. J. Med. Chem. V. 61 344 2018.
ISSN: ISSN 1520-4804
PubMed: 29206036
DOI: 10.1021/ACS.JMEDCHEM.7B01478
Page generated: Mon Oct 28 20:12:04 2024
ISSN: ISSN 1520-4804
PubMed: 29206036
DOI: 10.1021/ACS.JMEDCHEM.7B01478
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
