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Zinc in PDB 6ekn: Crystal Structure of MMP12 in Complex with Inhibitor BE7.Enzymatic activity of Crystal Structure of MMP12 in Complex with Inhibitor BE7.
All present enzymatic activity of Crystal Structure of MMP12 in Complex with Inhibitor BE7.:
3.4.24.65; Protein crystallography data
The structure of Crystal Structure of MMP12 in Complex with Inhibitor BE7., PDB code: 6ekn
was solved by
L.Ciccone,
L.Tepshi,
E.Nuti,
A.Rossello,
E.A.Stura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6ekn:
The structure of Crystal Structure of MMP12 in Complex with Inhibitor BE7. also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of MMP12 in Complex with Inhibitor BE7.
(pdb code 6ekn). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of MMP12 in Complex with Inhibitor BE7., PDB code: 6ekn: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 6eknGo back to Zinc Binding Sites List in 6ekn
Zinc binding site 1 out
of 2 in the Crystal Structure of MMP12 in Complex with Inhibitor BE7.
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 6eknGo back to Zinc Binding Sites List in 6ekn
Zinc binding site 2 out
of 2 in the Crystal Structure of MMP12 in Complex with Inhibitor BE7.
Mono view Stereo pair view
Reference:
E.Nuti,
D.Cuffaro,
E.Bernardini,
C.Camodeca,
L.Panelli,
S.Chaves,
L.Ciccone,
L.Tepshi,
L.Vera,
E.Orlandini,
S.Nencetti,
E.A.Stura,
M.A.Santos,
V.Dive,
A.Rossello.
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, uc(Nmr), and Crystallographic Studies. J. Med. Chem. V. 61 4421 2018.
Page generated: Wed Dec 16 11:43:18 2020
ISSN: ISSN 1520-4804 PubMed: 29727184 DOI: 10.1021/ACS.JMEDCHEM.8B00096 |
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