Zinc in PDB 6e0s: Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library

The structure of Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library, PDB code: 6e0s was solved by P.J.Stogios, T.Skarina, C.Lau, E.Topp, A.Savchenko, A.Joachimiak, K.J.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.36 / 1.78
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	45.313, 68.649, 78.588, 90.00, 90.00, 90.00
R / Rfree (%)	15.4 / 19.5

The binding sites of Zinc atom in the Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library (pdb code 6e0s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library, PDB code: 6e0s:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:30.9 occ:0.52 O A:HOH656 2.0 35.0 1.0 NE2 A:HIS91 2.3 21.2 1.0 NE2 A:HIS169 2.3 21.9 1.0 ND1 A:HIS93 2.4 23.3 1.0 O A:HOH469 2.7 46.9 1.0 CD2 A:HIS169 2.9 21.3 1.0 ZN A:ZN302 3.0 45.2 0.5 CD2 A:HIS91 3.0 21.5 1.0 CE1 A:HIS91 3.2 21.9 1.0 CE1 A:HIS93 3.2 24.3 1.0 CG A:HIS93 3.3 22.6 1.0 CE1 A:HIS169 3.5 23.0 1.0 O A:HOH458 3.6 44.9 1.0 CB A:HIS93 3.6 20.3 1.0 NE2 A:GLN132 4.0 24.8 1.0 CG A:HIS91 4.1 21.1 1.0 ND1 A:HIS91 4.2 21.4 1.0 CG A:HIS169 4.2 21.3 1.0 NE2 A:HIS93 4.3 24.4 1.0 CD2 A:HIS93 4.4 23.0 1.0 O A:HOH610 4.4 55.7 1.0 ND1 A:HIS169 4.4 22.2 1.0 O A:HOH676 4.5 58.7 1.0 CD2 A:HIS96 4.5 25.6 1.0 O A:HOH660 4.5 41.9 1.0 CG2 A:THR170 4.7 18.0 1.0 NE2 A:HIS96 4.9 25.8 1.0 O A:HOH590 4.9 31.3 1.0 CD A:GLN132 5.0 26.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mem-A1, A Subclass B3 Metallo-Beta-Lactamase Isolated From A Soil Metagenome Library within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:45.2 occ:0.53 O A:HOH656 1.8 35.0 1.0 O A:HOH469 1.8 46.9 1.0 O A:HOH458 2.1 44.9 1.0 O A:HOH676 2.4 58.7 1.0 ZN A:ZN301 3.0 30.9 0.5 NE2 A:HIS237 3.1 29.2 1.0 NE2 A:HIS96 3.2 25.8 1.0 CD2 A:HIS96 3.6 25.6 1.0 NE2 A:HIS91 3.8 21.2 1.0 CD2 A:HIS237 4.0 27.5 1.0 O A:HOH660 4.0 41.9 1.0 CE1 A:HIS237 4.1 28.9 1.0 NE2 A:HIS169 4.1 21.9 1.0 O A:HOH448 4.1 34.6 1.0 CE1 A:HIS91 4.2 21.9 1.0 O A:HOH610 4.3 55.7 1.0 O A:HOH678 4.4 66.8 1.0 CE1 A:HIS96 4.5 25.8 1.0 CB A:ASP95 4.6 28.3 1.0 O A:HOH590 4.6 31.3 1.0 OD1 A:ASP95 4.6 37.5 1.0 O A:HOH772 4.7 55.9 1.0 CE1 A:HIS169 4.8 23.0 1.0 ND1 A:HIS93 4.9 23.3 1.0 CG A:HIS96 4.9 23.7 1.0

P.J.Stogios, P.J.Stogios, T.Skarina, C.Lau, E.Topp, A.Savchenko, A.Joachimiak, K.J.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). N/A N/A.