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Zinc in PDB 6dcf: Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A
Enzymatic activity of Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A
All present enzymatic activity of Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A:
2.7.7.6;
2.7.7.6;
Protein crystallography data
The structure of Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A, PDB code: 6dcf
was solved by
M.Lilic,
S.A.Darst,
E.A.Campbell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.89 / 3.45 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 129.250, 160.909, 136.864, 90.00, 110.75, 90.00 |
| R / Rfree (%) | 25.2 / 29 |
Other elements in 6dcf:
The structure of Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A
(pdb code 6dcf). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A, PDB code: 6dcf:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A, PDB code: 6dcf:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 6dcf
Go back to
Zinc Binding Sites List in 6dcf
Zinc binding site 1 out
of 2 in the Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A within 5.0Å range:
|
Zinc binding site 2 out of 2 in 6dcf
Go back to
Zinc Binding Sites List in 6dcf
Zinc binding site 2 out
of 2 in the Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of A Mycobacterium Smegmatis Transcription Initiation Complex with Rifampicin-Resistant Rna Polymerase and Bound to Kanglemycin A within 5.0Å range:
|
Reference:
J.Peek,
M.Lilic,
D.Montiel,
A.Milshteyn,
I.Woodworth,
J.B.Biggins,
M.A.Ternei,
P.Y.Calle,
M.Danziger,
T.Warrier,
K.Saito,
N.Braffman,
A.Fay,
M.S.Glickman,
S.A.Darst,
E.A.Campbell,
S.F.Brady.
Rifamycin Congeners Kanglemycins Are Active Against Rifampicin-Resistant Bacteria Via A Distinct Mechanism. Nat Commun V. 9 4147 2018.
ISSN: ESSN 2041-1723
PubMed: 30297823
DOI: 10.1038/S41467-018-06587-2
Page generated: Mon Oct 28 19:26:41 2024
ISSN: ESSN 2041-1723
PubMed: 30297823
DOI: 10.1038/S41467-018-06587-2
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