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Zinc in PDB 6cw3: Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2

Enzymatic activity of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2

All present enzymatic activity of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2, PDB code: 6cw3 was solved by J.Sun, M.Paduch, S.A.Kim, R.M.Kramer, A.F.Barrios, V.Lu, J.Luke, S.Usatyuk, A.A.Kossiakoff, S.Tan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 88.22 / 1.98
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 101.657, 104.061, 166.335, 90.00, 90.00, 90.00
R / Rfree (%) 20.3 / 22.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 (pdb code 6cw3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2, PDB code: 6cw3:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 1 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn201

b:0.4
occ:1.00
 SG E:CYS7 2.4 62.6 1.0
SG E:CYS10 2.4 63.1 1.0
SG E:CYS31 2.4 80.9 1.0
SG E:CYS34 2.4 69.5 1.0
CB E:CYS7 3.2 63.1 1.0
CB E:CYS10 3.2 63.6 1.0
CB E:CYS34 3.2 60.2 1.0
CB E:CYS31 3.5 68.1 1.0
N E:CYS10 3.7 64.5 1.0
CA E:CYS10 4.0 69.5 1.0
N E:CYS31 4.1 60.5 1.0
CA E:CYS31 4.3 59.8 1.0
N E:CYS34 4.4 58.5 1.0
CA E:CYS34 4.4 60.5 1.0
CB E:VAL9 4.4 65.4 1.0
CA E:CYS7 4.6 63.9 1.0
O E:CYS31 4.7 58.7 1.0
C E:CYS10 4.7 65.5 1.0
C E:VAL9 4.8 65.2 1.0
CB E:ALA12 4.8 63.5 1.0
C E:CYS31 4.9 58.8 1.0
CG1 E:VAL9 4.9 63.5 1.0
CA E:VAL9 5.0 64.8 1.0
N E:SER11 5.0 65.8 1.0

Zinc binding site 2 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 2 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn202

b:55.5
occ:1.00
 ND1 E:HIS44 2.0 65.1 1.0
ND1 E:HIS48 2.2 65.0 1.0
SG E:CYS22 2.4 63.7 1.0
SG E:CYS25 2.5 67.6 1.0
CE1 E:HIS44 2.8 62.6 1.0
CG E:HIS44 3.0 64.4 1.0
CE1 E:HIS48 3.1 66.1 1.0
CG E:HIS48 3.2 65.4 1.0
CB E:CYS25 3.2 67.7 1.0
CB E:CYS22 3.4 63.4 1.0
CB E:HIS44 3.5 65.9 1.0
CB E:HIS48 3.5 66.3 1.0
N E:CYS25 3.6 67.1 1.0
CA E:HIS44 3.6 66.8 1.0
N E:ARG45 4.0 64.6 1.0
NE2 E:HIS44 4.0 62.7 1.0
CA E:CYS25 4.0 68.2 1.0
CD2 E:HIS44 4.1 63.3 1.0
NE2 E:HIS48 4.2 72.4 1.0
CD2 E:HIS48 4.3 66.2 1.0
C E:HIS44 4.4 65.7 1.0
O E:ARG45 4.4 61.9 1.0
CB E:ILE24 4.5 80.5 1.0
C E:ILE24 4.7 75.2 1.0
N E:HIS44 4.8 69.5 1.0
CA E:CYS22 4.8 65.6 1.0
CD1 E:TYR28 4.9 64.9 1.0
N E:ILE24 4.9 71.2 1.0
CA E:ILE24 4.9 73.5 1.0
CG E:TYR28 5.0 66.2 1.0

Zinc binding site 3 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 3 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn201

b:96.5
occ:1.00
 SG G:CYS34 2.3 73.6 1.0
SG G:CYS10 2.4 87.9 1.0
SG G:CYS31 2.5 81.6 1.0
SG G:CYS7 2.5 64.8 1.0
CB G:CYS34 3.0 65.7 1.0
CB G:CYS10 3.2 74.9 1.0
CB G:CYS7 3.2 63.3 1.0
CB G:CYS31 3.7 74.5 1.0
CG2 G:VAL9 3.8 73.7 1.0
N G:CYS10 3.9 85.7 1.0
N G:CYS31 4.0 55.8 1.0
CA G:CYS10 4.1 90.5 1.0
CA G:CYS34 4.3 58.8 1.0
CA G:CYS31 4.4 61.8 1.0
N G:CYS34 4.4 63.6 1.0
CA G:CYS7 4.7 63.2 1.0
C G:CYS10 4.7 88.0 1.0
C G:VAL9 4.9 94.3 1.0
O G:CYS31 4.9 58.2 1.0
CB G:ALA12 4.9 89.2 1.0
C G:CYS31 5.0 58.5 1.0
N G:SER11 5.0 82.0 1.0

Zinc binding site 4 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 4 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn202

b:0.1
occ:1.00
 ND1 G:HIS44 1.9 47.9 1.0
ND1 G:HIS48 2.0 66.4 1.0
SG G:CYS25 2.4 51.7 1.0
SG G:CYS22 2.5 50.5 1.0
CE1 G:HIS44 2.8 60.8 1.0
CE1 G:HIS48 3.0 74.5 1.0
CG G:HIS44 3.0 53.1 1.0
CG G:HIS48 3.1 64.7 1.0
CB G:CYS22 3.3 47.7 1.0
CB G:CYS25 3.4 52.1 1.0
CB G:HIS48 3.5 49.6 1.0
CB G:HIS44 3.5 49.9 1.0
CA G:HIS44 3.6 62.6 1.0
N G:CYS25 3.6 59.7 1.0
NE2 G:HIS44 3.9 51.4 1.0
N G:ARG45 4.0 66.1 1.0
CD2 G:HIS44 4.1 47.8 1.0
NE2 G:HIS48 4.1 76.7 1.0
CA G:CYS25 4.2 63.2 1.0
CD2 G:HIS48 4.2 77.2 1.0
CB G:ILE24 4.2 59.4 1.0
C G:HIS44 4.4 67.7 1.0
O G:ARG45 4.5 54.2 1.0
C G:ILE24 4.6 63.9 1.0
N G:HIS44 4.7 52.2 1.0
CA G:CYS22 4.7 49.5 1.0
CA G:ILE24 4.8 58.9 1.0
N G:ILE24 4.9 52.3 1.0
CG2 G:ILE24 4.9 71.2 1.0
CD2 G:TYR28 5.0 51.3 1.0
O G:LYS43 5.0 64.8 1.0
CG1 G:ILE24 5.0 56.8 1.0

Reference:

J.Sun, M.Paduch, S.A.Kim, R.M.Kramer, A.F.Barrios, V.Lu, J.Luke, S.Usatyuk, A.A.Kossiakoff, S.Tan. Structural Basis For Activation of Saga Histone Acetyltransferase GCN5 By Partner Subunit ADA2. Proc. Natl. Acad. Sci. V. 115 10010 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30224453
DOI: 10.1073/PNAS.1805343115
Page generated: Mon Oct 28 19:14:15 2024

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