Atomistry » Zinc » PDB 6cvs-6d5p » 6cw3
Atomistry »
  Zinc »
    PDB 6cvs-6d5p »
      6cw3 »

Zinc in PDB 6cw3: Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2

Enzymatic activity of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2

All present enzymatic activity of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2, PDB code: 6cw3 was solved by J.Sun, M.Paduch, S.A.Kim, R.M.Kramer, A.F.Barrios, V.Lu, J.Luke, S.Usatyuk, A.A.Kossiakoff, S.Tan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 88.22 / 1.98
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 101.657, 104.061, 166.335, 90.00, 90.00, 90.00
R / Rfree (%) 20.3 / 22.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 (pdb code 6cw3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2, PDB code: 6cw3:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 1 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn201

b:0.4
occ:1.00
 SG E:CYS7 2.4 62.6 1.0
SG E:CYS10 2.4 63.1 1.0
SG E:CYS31 2.4 80.9 1.0
SG E:CYS34 2.4 69.5 1.0
CB E:CYS7 3.2 63.1 1.0
CB E:CYS10 3.2 63.6 1.0
CB E:CYS34 3.2 60.2 1.0
CB E:CYS31 3.5 68.1 1.0
N E:CYS10 3.7 64.5 1.0
CA E:CYS10 4.0 69.5 1.0
N E:CYS31 4.1 60.5 1.0
CA E:CYS31 4.3 59.8 1.0
N E:CYS34 4.4 58.5 1.0
CA E:CYS34 4.4 60.5 1.0
CB E:VAL9 4.4 65.4 1.0
CA E:CYS7 4.6 63.9 1.0
O E:CYS31 4.7 58.7 1.0
C E:CYS10 4.7 65.5 1.0
C E:VAL9 4.8 65.2 1.0
CB E:ALA12 4.8 63.5 1.0
C E:CYS31 4.9 58.8 1.0
CG1 E:VAL9 4.9 63.5 1.0
CA E:VAL9 5.0 64.8 1.0
N E:SER11 5.0 65.8 1.0

Zinc binding site 2 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 2 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn202

b:55.5
occ:1.00
 ND1 E:HIS44 2.0 65.1 1.0
ND1 E:HIS48 2.2 65.0 1.0
SG E:CYS22 2.4 63.7 1.0
SG E:CYS25 2.5 67.6 1.0
CE1 E:HIS44 2.8 62.6 1.0
CG E:HIS44 3.0 64.4 1.0
CE1 E:HIS48 3.1 66.1 1.0
CG E:HIS48 3.2 65.4 1.0
CB E:CYS25 3.2 67.7 1.0
CB E:CYS22 3.4 63.4 1.0
CB E:HIS44 3.5 65.9 1.0
CB E:HIS48 3.5 66.3 1.0
N E:CYS25 3.6 67.1 1.0
CA E:HIS44 3.6 66.8 1.0
N E:ARG45 4.0 64.6 1.0
NE2 E:HIS44 4.0 62.7 1.0
CA E:CYS25 4.0 68.2 1.0
CD2 E:HIS44 4.1 63.3 1.0
NE2 E:HIS48 4.2 72.4 1.0
CD2 E:HIS48 4.3 66.2 1.0
C E:HIS44 4.4 65.7 1.0
O E:ARG45 4.4 61.9 1.0
CB E:ILE24 4.5 80.5 1.0
C E:ILE24 4.7 75.2 1.0
N E:HIS44 4.8 69.5 1.0
CA E:CYS22 4.8 65.6 1.0
CD1 E:TYR28 4.9 64.9 1.0
N E:ILE24 4.9 71.2 1.0
CA E:ILE24 4.9 73.5 1.0
CG E:TYR28 5.0 66.2 1.0

Zinc binding site 3 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 3 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn201

b:96.5
occ:1.00
 SG G:CYS34 2.3 73.6 1.0
SG G:CYS10 2.4 87.9 1.0
SG G:CYS31 2.5 81.6 1.0
SG G:CYS7 2.5 64.8 1.0
CB G:CYS34 3.0 65.7 1.0
CB G:CYS10 3.2 74.9 1.0
CB G:CYS7 3.2 63.3 1.0
CB G:CYS31 3.7 74.5 1.0
CG2 G:VAL9 3.8 73.7 1.0
N G:CYS10 3.9 85.7 1.0
N G:CYS31 4.0 55.8 1.0
CA G:CYS10 4.1 90.5 1.0
CA G:CYS34 4.3 58.8 1.0
CA G:CYS31 4.4 61.8 1.0
N G:CYS34 4.4 63.6 1.0
CA G:CYS7 4.7 63.2 1.0
C G:CYS10 4.7 88.0 1.0
C G:VAL9 4.9 94.3 1.0
O G:CYS31 4.9 58.2 1.0
CB G:ALA12 4.9 89.2 1.0
C G:CYS31 5.0 58.5 1.0
N G:SER11 5.0 82.0 1.0

Zinc binding site 4 out of 4 in 6cw3

Go back to Zinc Binding Sites List in 6cw3
Zinc binding site 4 out of 4 in the Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of A Yeast Saga Transcriptional Coactivator ADA2/GCN5 Hat Subcomplex, Crystal Form 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn202

b:0.1
occ:1.00
 ND1 G:HIS44 1.9 47.9 1.0
ND1 G:HIS48 2.0 66.4 1.0
SG G:CYS25 2.4 51.7 1.0
SG G:CYS22 2.5 50.5 1.0
CE1 G:HIS44 2.8 60.8 1.0
CE1 G:HIS48 3.0 74.5 1.0
CG G:HIS44 3.0 53.1 1.0
CG G:HIS48 3.1 64.7 1.0
CB G:CYS22 3.3 47.7 1.0
CB G:CYS25 3.4 52.1 1.0
CB G:HIS48 3.5 49.6 1.0
CB G:HIS44 3.5 49.9 1.0
CA G:HIS44 3.6 62.6 1.0
N G:CYS25 3.6 59.7 1.0
NE2 G:HIS44 3.9 51.4 1.0
N G:ARG45 4.0 66.1 1.0
CD2 G:HIS44 4.1 47.8 1.0
NE2 G:HIS48 4.1 76.7 1.0
CA G:CYS25 4.2 63.2 1.0
CD2 G:HIS48 4.2 77.2 1.0
CB G:ILE24 4.2 59.4 1.0
C G:HIS44 4.4 67.7 1.0
O G:ARG45 4.5 54.2 1.0
C G:ILE24 4.6 63.9 1.0
N G:HIS44 4.7 52.2 1.0
CA G:CYS22 4.7 49.5 1.0
CA G:ILE24 4.8 58.9 1.0
N G:ILE24 4.9 52.3 1.0
CG2 G:ILE24 4.9 71.2 1.0
CD2 G:TYR28 5.0 51.3 1.0
O G:LYS43 5.0 64.8 1.0
CG1 G:ILE24 5.0 56.8 1.0

Reference:

J.Sun, M.Paduch, S.A.Kim, R.M.Kramer, A.F.Barrios, V.Lu, J.Luke, S.Usatyuk, A.A.Kossiakoff, S.Tan. Structural Basis For Activation of Saga Histone Acetyltransferase GCN5 By Partner Subunit ADA2. Proc. Natl. Acad. Sci. V. 115 10010 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30224453
DOI: 10.1073/PNAS.1805343115
Page generated: Mon Oct 28 19:14:15 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy