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Atomistry » Zinc » PDB 6c6t-6cee » 6c7g | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 6c6t-6cee » 6c7g » |
Zinc in PDB 6c7g: Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-CarboxamideEnzymatic activity of Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide
All present enzymatic activity of Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide:
3.1.4.17; Protein crystallography data
The structure of Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide, PDB code: 6c7g
was solved by
R.Xu,
K.Aertgeerts,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6c7g:
The structure of Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide
(pdb code 6c7g). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide, PDB code: 6c7g: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 6c7gGo back to Zinc Binding Sites List in 6c7g
Zinc binding site 1 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 6c7gGo back to Zinc Binding Sites List in 6c7g
Zinc binding site 2 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 6c7gGo back to Zinc Binding Sites List in 6c7g
Zinc binding site 3 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 6c7gGo back to Zinc Binding Sites List in 6c7g
Zinc binding site 4 out
of 4 in the Crystal Structure of Human Phosphodiesterase 2A with N-(1-Adamantyl)- 1-(2-Chloro-5-Isobutoxy-Phenyl)-4-Methyl-[1,2,4]Triazolo[4,3- A]Quinoxaline-8-Carboxamide
Mono view Stereo pair view
Reference:
L.Gomez,
R.Xu,
W.Sinko,
B.Selfridge,
W.Vernier,
K.Ly,
R.Truong,
M.Metz,
T.Marrone,
K.Sebring,
Y.Yan,
B.Appleton,
K.Aertgeerts,
M.E.Massari,
J.G.Breitenbucher.
Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused By Protein Conformational Changes. J. Med. Chem. V. 61 7754 2018.
Page generated: Mon Oct 28 18:32:00 2024
ISSN: ISSN 1520-4804 PubMed: 30070482 DOI: 10.1021/ACS.JMEDCHEM.8B00713 |
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