Zinc in PDB 6c06: Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin

All present enzymatic activity of Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin:
2.7.7.6;

The structure of Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Chlorine	(Cl)	2 atoms

The binding sites of Zinc atom in the Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin (pdb code 6c06). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin, PDB code: 6c06:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1401 b:0.4 occ:1.00 SG D:CYS975 2.1 0.7 1.0 CB D:CYS891 2.2 0.1 1.0 CG2 D:THR970 2.3 0.6 1.0 SG D:CYS978 2.4 0.5 1.0 CB D:CYS975 2.5 0.7 1.0 SG D:CYS968 2.7 0.1 1.0 N D:CYS975 2.8 0.7 1.0 CA D:CYS891 2.9 0.1 1.0 N D:CYS891 2.9 0.1 1.0 CB D:CYS978 3.0 0.5 1.0 CA D:CYS975 3.1 0.7 1.0 SG D:CYS891 3.4 0.1 1.0 CB D:THR970 3.4 0.6 1.0 OG1 D:THR970 3.5 0.6 1.0 N D:THR970 3.6 0.6 1.0 C D:VAL974 3.6 0.3 1.0 O D:CYS975 3.8 0.7 1.0 C D:CYS975 3.9 0.7 1.0 N D:CYS978 3.9 0.5 1.0 CA D:CYS978 4.0 0.5 1.0 CB D:CYS968 4.0 0.1 1.0 OE2 D:GLU888 4.0 0.7 1.0 CA D:VAL974 4.1 0.3 1.0 OG1 D:THR977 4.1 0.5 1.0 CA D:THR970 4.1 0.6 1.0 NH1 D:ARG963 4.1 0.9 1.0 C D:ASP890 4.2 0.2 1.0 CA D:CYS968 4.3 0.1 1.0 N D:ALA969 4.3 1.0 1.0 C D:CYS891 4.3 0.1 1.0 C D:CYS968 4.5 0.1 1.0 O D:VAL974 4.6 0.3 1.0 CB D:VAL974 4.7 0.3 1.0 C D:ALA969 4.7 1.0 1.0 CG D:GLU888 4.8 0.7 1.0 CD D:GLU888 4.8 0.7 1.0 N D:GLN892 4.8 0.2 1.0 O D:HIS889 4.9 0.1 1.0 CA D:ASP890 4.9 0.2 1.0 CA D:ALA969 4.9 1.0 1.0

Zinc binding site 2 out of 2 in the Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mycobacterium Tuberculosis Rnap Holo/Rbpa/Fidaxomicin within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1402 b:0.4 occ:1.00 O D:CYS60 1.8 0.8 1.0 N D:CYS62 1.9 0.7 1.0 C D:CYS60 2.1 0.8 1.0 SG D:CYS62 2.1 0.7 1.0 SG D:CYS78 2.2 0.0 1.0 CA D:CYS62 2.3 0.7 1.0 C D:CYS62 2.4 0.7 1.0 C D:TYR61 2.6 0.5 1.0 CB D:CYS62 2.6 0.7 1.0 N D:TYR61 2.6 0.5 1.0 O D:CYS62 2.9 0.7 1.0 N D:GLY63 3.0 0.2 1.0 CB D:CYS60 3.0 0.8 1.0 SG D:CYS60 3.0 0.8 1.0 CA D:CYS60 3.1 0.8 1.0 NZ D:LYS64 3.1 1.0 1.0 CA D:TYR61 3.2 0.5 1.0 CB D:CYS78 3.5 0.0 1.0 O D:TYR61 3.5 0.5 1.0 C D:GLY63 3.6 0.2 1.0 O D:GLY63 3.7 0.2 1.0 CA D:GLY63 3.8 0.2 1.0 SG D:CYS75 3.8 0.6 1.0 CB D:LYS64 3.9 1.0 1.0 N D:CYS60 4.1 0.8 1.0 N D:LYS64 4.1 1.0 1.0 CB D:TYR61 4.2 0.5 1.0 N D:CYS78 4.3 0.0 1.0 CA D:CYS78 4.5 0.0 1.0 CE D:LYS64 4.5 1.0 1.0 O D:GLU59 4.6 0.1 1.0 CA D:LYS64 4.6 1.0 1.0 C D:GLU59 4.8 0.1 1.0 CZ D:ARG77 4.8 0.3 1.0 NE D:ARG77 4.9 0.3 1.0 NH2 D:ARG77 4.9 0.3 1.0 CB D:ARG77 4.9 0.3 1.0 CB D:CYS75 4.9 0.6 1.0 CD D:LYS64 5.0 1.0 1.0 CG D:LYS64 5.0 1.0 1.0

H.Boyaci, J.Chen, M.Lilic, M.Palka, R.A.Mooney, R.Landick, S.A.Darst, E.A.Campbell. Fidaxomicin Jamsmycobacterium Tuberculosisrna Polymerase Motions Needed For Initiation Via Rbpa Contacts. Elife V. 7 2018.
ISSN: ESSN 2050-084X
PubMed: 29480804
DOI: 10.7554/ELIFE.34823