Atomistry » Zinc » PDB 6bml-6bvd » 6bn9
Atomistry »
  Zinc »
    PDB 6bml-6bvd »
      6bn9 »

Zinc in PDB 6bn9: Crystal Structure of DDB1-Crbn-BRD4(BD1) Complex Bound to DBET70 Protac

Protein crystallography data

The structure of Crystal Structure of DDB1-Crbn-BRD4(BD1) Complex Bound to DBET70 Protac, PDB code: 6bn9 was solved by R.P.Nowak, S.L.Deangelo, D.Buckley, J.E.Bradner, E.S.Fischer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 100.40 / 4.38
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 117.604, 117.604, 597.157, 90.00, 90.00, 120.00
R / Rfree (%) 27.5 / 30.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of DDB1-Crbn-BRD4(BD1) Complex Bound to DBET70 Protac (pdb code 6bn9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of DDB1-Crbn-BRD4(BD1) Complex Bound to DBET70 Protac, PDB code: 6bn9:

Zinc binding site 1 out of 1 in 6bn9

Go back to Zinc Binding Sites List in 6bn9
Zinc binding site 1 out of 1 in the Crystal Structure of DDB1-Crbn-BRD4(BD1) Complex Bound to DBET70 Protac


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of DDB1-Crbn-BRD4(BD1) Complex Bound to DBET70 Protac within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn501

b:0.1
occ:1.00
SG B:CYS326 2.3 0.9 1.0
SG B:CYS391 2.3 0.9 1.0
SG B:CYS394 2.6 0.3 1.0
SG B:CYS323 2.6 0.3 1.0
CB B:CYS323 2.9 0.6 1.0
CB B:CYS326 2.9 0.0 1.0
CB B:CYS391 3.2 0.5 1.0
N B:CYS326 3.7 0.8 1.0
CB B:CYS394 3.8 0.5 1.0
CA B:CYS326 3.9 0.4 1.0
N B:CYS394 4.0 0.6 1.0
CB B:THR329 4.3 0.8 1.0
CA B:CYS323 4.3 0.6 1.0
OG1 B:THR329 4.4 0.6 1.0
CA B:CYS394 4.5 0.3 1.0
CG2 B:THR329 4.6 0.9 1.0
CA B:CYS391 4.6 0.9 1.0
C B:GLN325 4.7 1.0 1.0
CB B:ILE393 4.7 0.7 1.0
CB B:GLN325 4.9 0.8 1.0
C B:CYS323 4.9 0.6 1.0

Reference:

R.P.Nowak, S.L.Deangelo, D.Buckley, Z.He, K.A.Donovan, J.An, N.Safaee, M.P.Jedrychowski, C.M.Ponthier, M.Ishoey, T.Zhang, J.D.Mancias, N.S.Gray, J.E.Bradner, E.S.Fischer. Plasticity in Binding Confers Selectivity in Ligand-Induced Protein Degradation. Nat. Chem. Biol. V. 14 706 2018.
ISSN: ESSN 1552-4469
PubMed: 29892083
DOI: 10.1038/S41589-018-0055-Y
Page generated: Wed Dec 16 11:32:44 2020

Last articles

Zn in 7NN0
Zn in 7NIO
Zn in 7LUP
Zn in 7M1Y
Zn in 7LO4
Zn in 7KWO
Zn in 7KJY
Zn in 7KCQ
Zn in 7KC2
Zn in 7KCB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy