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Atomistry » Zinc » PDB 6av1-6bd4 » 6av3 » |
Zinc in PDB 6av3: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-AmineEnzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine, PDB code: 6av3
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6av3:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
(pdb code 6av3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine, PDB code: 6av3: Zinc binding site 1 out of 1 in 6av3Go back to Zinc Binding Sites List in 6av3
Zinc binding site 1 out
of 1 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(3-((Methylamino) Methyl)Phenyl)Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
Mono view Stereo pair view
Reference:
H.T.Do,
H.Y.Wang,
H.Li,
G.Chreifi,
T.L.Poulos,
R.B.Silverman.
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with A Fluorobenzene Linker. J. Med. Chem. V. 60 9360 2017.
Page generated: Mon Oct 28 17:45:01 2024
ISSN: ISSN 1520-4804 PubMed: 29091437 DOI: 10.1021/ACS.JMEDCHEM.7B01356 |
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