Zinc in PDB 6at1: Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution

Enzymatic activity of Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution

All present enzymatic activity of Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution:
2.1.3.2;

Protein crystallography data

The structure of Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution, PDB code: 6at1 was solved by R.C.Stevens, J.E.Gouaux, W.N.Lipscomb, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.60
Space group P 3 2 1
Cell size a, b, c (Å), α, β, γ (°) 122.000, 122.000, 142.000, 90.00, 90.00, 120.00
R / Rfree (%) 16 / n/a

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution (pdb code 6at1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution, PDB code: 6at1:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6at1

Go back to Zinc Binding Sites List in 6at1
Zinc binding site 1 out of 2 in the Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn154

b:9.7
occ:1.00
 SG B:CYS141 2.3 16.6 1.0
SG B:CYS109 2.3 11.6 1.0
SG B:CYS114 2.3 8.9 1.0
SG B:CYS138 2.3 16.3 1.0
CB B:CYS138 3.0 12.6 1.0
CB B:CYS114 3.1 13.0 1.0
CB B:CYS109 3.2 6.0 1.0
CB B:CYS141 3.4 7.0 1.0
N B:CYS141 3.8 7.5 1.0
CB B:ASN111 4.2 7.6 1.0
CA B:CYS141 4.3 6.7 1.0
OG B:SER116 4.4 14.8 1.0
CA B:CYS114 4.4 16.0 1.0
CA B:CYS138 4.4 10.6 1.0
ND2 B:ASN111 4.5 11.2 1.0
CA B:CYS109 4.6 10.5 1.0
CB B:TYR140 4.8 7.7 1.0
CG B:ASN111 4.9 7.6 1.0
CE1 B:PHE145 4.9 7.9 1.0
C B:TYR140 4.9 7.7 1.0

Zinc binding site 2 out of 2 in 6at1

Go back to Zinc Binding Sites List in 6at1
Zinc binding site 2 out of 2 in the Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase. Crystal Structures of the Unligated and Atp-, and Ctp-Complexed Enzymes at 2.6-Angstroms Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn154

b:14.9
occ:1.00
 SG D:CYS114 2.3 8.2 1.0
SG D:CYS138 2.3 16.0 1.0
SG D:CYS109 2.3 16.0 1.0
SG D:CYS141 2.3 17.8 1.0
CB D:CYS114 3.1 6.3 1.0
CB D:CYS138 3.2 15.2 1.0
CB D:CYS141 3.2 15.4 1.0
CB D:CYS109 3.2 14.7 1.0
N D:CYS141 3.6 15.7 1.0
CA D:CYS141 4.0 14.6 1.0
CA D:CYS114 4.3 3.5 1.0
OG D:SER116 4.3 15.0 1.0
CB D:ASN111 4.4 8.4 1.0
CA D:CYS109 4.5 14.8 1.0
ND2 D:ASN111 4.6 18.8 1.0
CB D:TYR140 4.6 11.7 1.0
CA D:CYS138 4.7 13.5 1.0
C D:TYR140 4.8 15.9 1.0
C D:CYS141 4.8 14.4 1.0

Reference:

R.C.Stevens, J.E.Gouaux, W.N.Lipscomb. Structural Consequences of Effector Binding to the T State of Aspartate Carbamoyltransferase: Crystal Structures of the Unligated and Atp- and Ctp-Complexed Enzymes at 2.6-A Resolution. Biochemistry V. 29 7691 1990.
ISSN: ISSN 0006-2960
PubMed: 2271528
DOI: 10.1021/BI00485A019
Page generated: Wed Dec 16 11:30:24 2020

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