Atomistry » Zinc » PDB 6agb-6av0 » 6ago
Atomistry »
  Zinc »
    PDB 6agb-6av0 »
      6ago »

Zinc in PDB 6ago: Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex

Enzymatic activity of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex

All present enzymatic activity of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex:
2.1.1.43;

Protein crystallography data

The structure of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex, PDB code: 6ago was solved by Y.Lee, J.Song, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.92 / 3.10
Space group P 31 1 2
Cell size a, b, c (Å), α, β, γ (°) 115.757, 115.757, 209.282, 90.00, 90.00, 120.00
R / Rfree (%) 22 / 27.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex (pdb code 6ago). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex, PDB code: 6ago:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6;

Zinc binding site 1 out of 6 in 6ago

Go back to Zinc Binding Sites List in 6ago
Zinc binding site 1 out of 6 in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2302

b:0.2
occ:1.00
 SG A:CYS2270 2.4 0.9 1.0
SG A:CYS2220 2.4 0.1 1.0
SG A:CYS2275 2.6 0.8 1.0
CB A:CYS2270 2.9 0.9 1.0
SG A:CYS2268 3.3 0.1 1.0
CB A:CYS2220 3.6 0.1 1.0
CB A:CYS2275 3.6 0.6 1.0
N A:CYS2220 3.9 0.5 1.0
N A:CYS2270 3.9 0.0 1.0
CA A:CYS2275 3.9 0.1 1.0
CA A:CYS2270 4.0 0.3 1.0
N A:ARG2276 4.1 0.1 1.0
CA A:CYS2220 4.3 0.3 1.0
C A:CYS2275 4.5 0.3 1.0
N A:GLY2271 4.5 0.9 1.0
C A:CYS2270 4.7 0.2 1.0
CB A:CYS2268 4.9 0.5 1.0
N A:PHE2272 4.9 0.9 1.0
NE2 A:HIS2218 4.9 0.8 1.0
C A:SER2219 4.9 0.6 1.0
CB A:PHE2272 4.9 0.1 1.0

Zinc binding site 2 out of 6 in 6ago

Go back to Zinc Binding Sites List in 6ago
Zinc binding site 2 out of 6 in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2303

b:0.3
occ:1.00
 SG A:CYS2091 2.4 95.7 1.0
SG A:CYS2108 2.4 1.0 1.0
SG A:CYS2104 2.4 0.8 1.0
SG A:CYS2093 2.5 0.7 1.0
CB A:CYS2108 2.7 97.4 1.0
CB A:CYS2091 2.9 0.8 1.0
CB A:CYS2104 2.9 0.3 1.0
CB A:CYS2093 3.5 0.1 1.0
CA A:CYS2108 3.6 0.3 1.0
ZN A:ZN2304 3.6 0.2 1.0
CA A:CYS2104 3.7 0.8 1.0
SG A:CYS2117 4.0 96.0 1.0
CA A:CYS2091 4.3 0.6 1.0
N A:LEU2109 4.4 0.6 1.0
C A:CYS2108 4.4 0.5 1.0
O A:CYS2091 4.6 0.3 1.0
N A:CYS2104 4.6 0.9 1.0
N A:CYS2108 4.7 1.0 1.0
C A:CYS2091 4.7 0.0 1.0
CA A:CYS2093 4.7 0.7 1.0
N A:CYS2093 4.7 0.3 1.0
C A:CYS2104 4.8 0.9 1.0

Zinc binding site 3 out of 6 in 6ago

Go back to Zinc Binding Sites List in 6ago
Zinc binding site 3 out of 6 in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2304

b:0.2
occ:1.00
 SG A:CYS2122 2.3 98.1 1.0
SG A:CYS2117 2.4 96.0 1.0
SG A:CYS2104 2.5 0.8 1.0
SG A:CYS2128 2.5 1.0 1.0
CB A:CYS2117 3.1 99.0 1.0
CB A:CYS2122 3.5 89.2 1.0
CB A:CYS2104 3.6 0.3 1.0
CB A:CYS2128 3.6 93.8 1.0
SG A:CYS2091 3.6 95.7 1.0
ZN A:ZN2303 3.6 0.3 1.0
CB A:ASN2130 4.4 1.0 1.0
CA A:CYS2128 4.5 0.5 1.0
CA A:CYS2117 4.6 84.2 1.0
CA A:CYS2122 4.6 92.2 1.0
CB A:CYS2124 4.7 0.8 1.0
NE2 A:GLN2131 4.9 0.7 1.0
SG A:CYS2108 4.9 1.0 1.0
N A:ASN2130 5.0 97.6 1.0
CA A:CYS2104 5.0 0.8 1.0

Zinc binding site 4 out of 6 in 6ago

Go back to Zinc Binding Sites List in 6ago
Zinc binding site 4 out of 6 in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn2301

b:0.9
occ:1.00
 SG B:CYS2270 2.5 0.5 1.0
CB B:CYS2270 2.7 0.4 1.0
N B:CYS2270 3.2 0.1 1.0
CA B:CYS2275 3.4 0.6 1.0
O B:CYS2268 3.4 0.5 1.0
O B:CYS2275 3.5 0.3 1.0
CA B:CYS2270 3.5 0.1 1.0
SG B:CYS2220 3.5 0.5 1.0
SG B:CYS2275 3.6 0.9 1.0
CB B:CYS2275 3.8 0.3 1.0
C B:CYS2275 3.9 0.6 1.0
C B:CYS2268 4.0 0.4 1.0
C B:LYS2269 4.1 0.7 1.0
N B:GLY2271 4.2 0.8 1.0
SG B:CYS2268 4.2 0.1 1.0
C B:CYS2270 4.3 0.4 1.0
O B:LYS2274 4.4 0.2 1.0
N B:CYS2275 4.4 0.9 1.0
CB B:CYS2268 4.5 0.6 1.0
CA B:LYS2269 4.5 0.5 1.0
N B:LYS2269 4.5 0.8 1.0
CB B:CYS2220 4.7 0.4 1.0
C B:LYS2274 4.8 0.6 1.0
CA B:CYS2268 4.9 0.2 1.0

Zinc binding site 5 out of 6 in 6ago

Go back to Zinc Binding Sites List in 6ago
Zinc binding site 5 out of 6 in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn2302

b:95.9
occ:1.00
 SG B:CYS2108 2.3 0.5 1.0
CB B:CYS2091 2.3 0.6 1.0
CB B:CYS2108 2.4 0.3 1.0
SG B:CYS2091 2.5 96.8 1.0
SG B:CYS2104 2.7 0.6 1.0
CB B:CYS2104 3.5 98.0 1.0
ZN B:ZN2303 3.7 98.0 1.0
CA B:CYS2091 3.8 0.9 1.0
SG B:CYS2117 3.8 95.7 1.0
CA B:CYS2108 3.9 0.3 1.0
O B:CYS2091 4.1 0.2 1.0
CB B:ASN2110 4.3 0.6 1.0
C B:CYS2091 4.3 0.7 1.0
SG B:CYS2093 4.4 0.4 1.0
CA B:CYS2104 4.5 0.9 1.0
C B:CYS2108 4.5 0.1 1.0
N B:ASN2110 4.7 0.8 1.0
N B:CYS2091 4.8 0.1 1.0
N B:LEU2109 4.8 0.3 1.0
N B:CYS2108 4.8 0.5 1.0
CB B:CYS2093 4.9 0.8 1.0
ND2 B:ASN2110 4.9 89.7 1.0

Zinc binding site 6 out of 6 in 6ago

Go back to Zinc Binding Sites List in 6ago
Zinc binding site 6 out of 6 in the Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Crystal Structure of MRG15-ASH1L Histone Methyltransferase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn2303

b:98.0
occ:1.00
 SG B:CYS2122 2.3 96.0 1.0
SG B:CYS2117 2.4 95.7 1.0
SG B:CYS2128 2.5 0.6 1.0
SG B:CYS2104 2.8 0.6 1.0
CB B:CYS2117 3.0 87.6 1.0
CB B:CYS2122 3.2 94.9 1.0
SG B:CYS2091 3.6 96.8 1.0
CB B:CYS2128 3.7 97.7 1.0
ZN B:ZN2302 3.7 95.9 1.0
CB B:CYS2104 4.3 98.0 1.0
CA B:CYS2122 4.3 0.1 1.0
CB B:CYS2091 4.4 0.6 1.0
CB B:ASN2130 4.5 0.8 1.0
CA B:CYS2117 4.5 87.1 1.0
NE2 B:GLN2131 4.7 0.9 1.0
CA B:CYS2128 4.8 0.5 1.0
CB B:CYS2124 5.0 0.3 1.0

Reference:

Y.Lee, E.Yoon, S.Cho, S.Schmahling, J.Muller, J.J.Song. Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase By Releasing An Autoinhibitory Loop. Structure V. 27 846 2019.
ISSN: ISSN 0969-2126
PubMed: 30827841
DOI: 10.1016/J.STR.2019.01.016
Page generated: Mon Oct 28 17:31:38 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy