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Zinc in PDB 5zqo: Tankyrase-2 in Complex with Compound 1AEnzymatic activity of Tankyrase-2 in Complex with Compound 1A
All present enzymatic activity of Tankyrase-2 in Complex with Compound 1A:
2.4.2.30; Protein crystallography data
The structure of Tankyrase-2 in Complex with Compound 1A, PDB code: 5zqo
was solved by
H.Niwa,
F.Shirai,
S.Sato,
N.Yoshimoto,
T.Tsumura,
M.Okue,
M.Shirouzu,
H.Seimiya,
T.Umehara,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Tankyrase-2 in Complex with Compound 1A
(pdb code 5zqo). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Tankyrase-2 in Complex with Compound 1A, PDB code: 5zqo: Zinc binding site 1 out of 1 in 5zqoGo back to Zinc Binding Sites List in 5zqo
Zinc binding site 1 out
of 1 in the Tankyrase-2 in Complex with Compound 1A
Mono view Stereo pair view
Reference:
F.Shirai,
T.Tsumura,
Y.Yashiroda,
H.Yuki,
H.Niwa,
S.Sato,
T.Chikada,
Y.Koda,
K.Washizuka,
N.Yoshimoto,
M.Abe,
T.Onuki,
Y.Mazaki,
C.Hirama,
T.Fukami,
H.Watanabe,
T.Honma,
T.Umehara,
M.Shirouzu,
M.Okue,
Y.Kano,
T.Watanabe,
K.Kitamura,
E.Shitara,
Y.Muramatsu,
H.Yoshida,
A.Mizutani,
H.Seimiya,
M.Yoshida,
H.Koyama.
Discovery of Novel Spiroindoline Derivatives As Selective Tankyrase Inhibitors. J. Med. Chem. V. 62 3407 2019.
Page generated: Wed Dec 16 11:27:41 2020
ISSN: ISSN 1520-4804 PubMed: 30883102 DOI: 10.1021/ACS.JMEDCHEM.8B01888 |
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