Zinc in PDB 5x45: Crystal Structure of 2A Protease From Human Rhinovirus C15

The structure of Crystal Structure of 2A Protease From Human Rhinovirus C15, PDB code: 5x45 was solved by H.Ling, P.Yang, N.Shaw, Y.Sun, X.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.69 / 2.60
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	80.992, 85.370, 208.908, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / 21.5

The binding sites of Zinc atom in the Crystal Structure of 2A Protease From Human Rhinovirus C15 (pdb code 5x45). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of 2A Protease From Human Rhinovirus C15, PDB code: 5x45:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of 2A Protease From Human Rhinovirus C15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of 2A Protease From Human Rhinovirus C15 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:70.7 occ:1.00 SG A:CYS51 1.9 53.7 1.0 ND1 A:HIS113 2.5 61.2 1.0 SG A:CYS111 2.5 46.7 1.0 SG A:CYS53 2.6 99.8 1.0 CB A:CYS51 3.2 51.0 1.0 CB A:CYS53 3.3 49.6 1.0 CG A:HIS113 3.4 60.0 1.0 CE1 A:HIS113 3.5 66.6 1.0 CB A:CYS111 3.5 27.2 1.0 CB A:HIS113 3.6 33.7 1.0 N A:HIS113 4.0 31.5 1.0 N A:CYS53 4.4 58.2 1.0 CA A:HIS113 4.4 40.1 1.0 CA A:CYS53 4.5 59.6 1.0 N A:LYS112 4.5 36.0 1.0 NE2 A:HIS113 4.6 71.4 1.0 CD2 A:HIS113 4.6 63.4 1.0 CA A:CYS51 4.6 48.6 1.0 CA A:CYS111 4.8 26.6 1.0 CG A:PRO49 4.8 32.8 1.0 CB A:PRO49 4.8 35.1 1.0 C A:CYS111 4.9 27.9 1.0 O A:HOH323 5.0 44.8 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of 2A Protease From Human Rhinovirus C15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of 2A Protease From Human Rhinovirus C15 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:69.7 occ:1.00 SG B:CYS111 2.4 51.5 1.0 ND1 B:HIS113 2.5 53.8 1.0 SG B:CYS51 2.6 62.8 1.0 SG B:CYS53 2.7 81.0 1.0 CB B:CYS53 3.4 51.7 1.0 CG B:HIS113 3.4 47.6 1.0 CB B:CYS111 3.4 23.1 1.0 CE1 B:HIS113 3.4 50.9 1.0 CB B:HIS113 3.6 36.1 1.0 CB B:CYS51 3.6 49.9 1.0 N B:HIS113 3.9 33.4 1.0 CA B:HIS113 4.3 30.2 1.0 N B:LYS112 4.4 31.7 1.0 N B:CYS53 4.4 56.2 1.0 CA B:CYS53 4.5 55.9 1.0 CD2 B:HIS113 4.5 51.0 1.0 NE2 B:HIS113 4.5 58.1 1.0 CA B:CYS111 4.6 23.7 1.0 C B:CYS111 4.7 24.6 1.0 CG B:PRO49 4.9 29.9 1.0 C B:LYS112 5.0 36.8 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of 2A Protease From Human Rhinovirus C15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of 2A Protease From Human Rhinovirus C15 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:0.1 occ:1.00 ND1 C:HIS113 2.3 54.5 1.0 SG C:CYS111 2.4 56.9 1.0 SG C:CYS51 2.5 48.2 1.0 SG C:CYS53 2.5 0.7 1.0 CE1 C:HIS113 3.0 56.8 1.0 CB C:CYS53 3.1 41.4 1.0 CB C:CYS111 3.2 24.1 1.0 CG C:HIS113 3.4 54.1 1.0 CB C:CYS51 3.5 49.8 1.0 O C:HOH321 3.8 41.1 1.0 CB C:HIS113 3.9 43.2 1.0 N C:HIS113 4.1 28.7 1.0 NE2 C:HIS113 4.2 59.7 1.0 N C:CYS53 4.3 44.0 1.0 N C:LYS112 4.3 26.9 1.0 CA C:CYS53 4.3 45.4 1.0 CD2 C:HIS113 4.4 56.5 1.0 CA C:CYS111 4.5 23.6 1.0 CA C:HIS113 4.7 37.8 1.0 C C:CYS111 4.7 25.1 1.0 CA C:CYS51 4.9 53.3 1.0 N C:ASP52 4.9 59.9 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of 2A Protease From Human Rhinovirus C15


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of 2A Protease From Human Rhinovirus C15 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn201 b:76.8 occ:1.00 SG D:CYS51 2.5 73.0 1.0 ND1 D:HIS113 2.5 55.4 1.0 SG D:CYS111 2.6 53.5 1.0 SG D:CYS53 3.0 0.5 1.0 CB D:CYS53 3.2 50.8 1.0 CE1 D:HIS113 3.4 61.5 1.0 CB D:CYS51 3.5 50.0 1.0 CB D:CYS111 3.5 35.2 1.0 CG D:HIS113 3.5 52.1 1.0 CB D:HIS113 3.8 48.7 1.0 N D:HIS113 4.0 49.2 1.0 N D:CYS53 4.3 58.7 1.0 CA D:CYS53 4.3 60.5 1.0 N D:LYS112 4.4 34.5 1.0 CA D:HIS113 4.5 47.2 1.0 NE2 D:HIS113 4.6 58.7 1.0 CD2 D:HIS113 4.6 51.6 1.0 CA D:CYS111 4.8 34.0 1.0 C D:CYS111 4.8 31.9 1.0 CA D:CYS51 4.9 60.3 1.0 CG D:PRO49 4.9 41.1 1.0 N D:ASP52 5.0 65.4 1.0

H.Ling, P.Yang, H.Hou, Y.Sun. Structural View of the 2A Protease From Human Rhinovirus C15 Acta Crystallogr.,Sect.F V. 74 255 2018.
ISSN: ESSN 2053-230X
DOI: 10.1107/S2053230X18003382