Zinc in PDB 5wz3: Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp)

The structure of Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp), PDB code: 5wz3 was solved by W.Duan, H.Song, J.Qi, Y.Shi, G.F.Gao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.16 / 1.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	63.528, 84.851, 69.199, 90.00, 113.37, 90.00
R / Rfree (%)	17.8 / 20.6

The binding sites of Zinc atom in the Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp) (pdb code 5wz3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp), PDB code: 5wz3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:14.2 occ:1.00 NE2 A:HIS714 2.0 14.5 1.0 O A:HOH1055 2.1 13.6 1.0 SG A:CYS849 2.3 15.2 1.0 SG A:CYS730 2.3 11.1 1.0 CE1 A:HIS714 3.0 17.8 1.0 CD2 A:HIS714 3.1 13.1 1.0 CB A:CYS730 3.2 10.4 1.0 CB A:CYS849 3.4 13.7 1.0 O A:HOH1374 3.7 23.6 1.0 ND1 A:HIS714 4.1 14.4 1.0 CG A:HIS714 4.2 10.6 1.0 C A:CYS730 4.3 13.2 1.0 ND2 A:ASN716 4.3 18.0 1.0 CA A:CYS730 4.3 6.6 1.0 N A:ARG731 4.3 10.7 1.0 CD1 A:LEU841 4.4 14.0 1.0 O A:HOH1438 4.7 40.7 1.0 O A:CYS730 4.7 7.5 1.0 O A:HOH1444 4.7 27.2 1.0 CA A:CYS849 4.7 9.3 1.0 NH1 A:ARG771 4.8 11.2 1.0 O A:GLU845 4.8 12.0 1.0 O A:ARG731 4.8 12.5 1.0 CA A:ARG731 4.8 14.5 1.0 C A:ARG731 4.9 13.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Zika Virus NS5 Rna-Dependent Rna Polymerase(Rdrp) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn902 b:22.8 occ:1.00 NE2 A:HIS443 2.0 26.0 1.0 OE2 A:GLU439 2.1 24.4 1.0 SG A:CYS448 2.3 22.4 1.0 SG A:CYS451 2.3 27.3 1.0 CE1 A:HIS443 2.9 22.9 1.0 CD A:GLU439 3.1 36.1 1.0 CD2 A:HIS443 3.1 24.8 1.0 CB A:CYS451 3.1 23.9 1.0 CB A:CYS448 3.3 25.5 1.0 CG A:GLU439 3.4 29.9 1.0 CA A:CYS448 3.7 26.9 1.0 N A:CYS451 3.7 27.3 1.0 CA A:CYS451 4.0 24.6 1.0 ND1 A:HIS443 4.1 26.2 1.0 N A:GLN449 4.1 29.1 1.0 CG A:HIS443 4.2 25.7 1.0 OE1 A:GLU439 4.2 35.0 1.0 C A:CYS448 4.3 28.6 1.0 N A:SER450 4.4 30.4 1.0 C A:SER450 4.7 33.1 1.0 O A:GLU447 4.9 33.5 1.0 OG A:SER450 4.9 44.8 1.0 CB A:GLU439 4.9 34.2 1.0

W.Duan, H.Song, H.Wang, Y.Chai, C.Su, J.Qi, Y.Shi, G.F.Gao. The Crystal Structure of Zika Virus NS5 Reveals Conserved Drug Targets. Embo J. V. 36 919 2017.
ISSN: ESSN 1460-2075
PubMed: 28254839
DOI: 10.15252/EMBJ.201696241