Zinc in PDB 5waw: Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery

The structure of Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery, PDB code: 5waw was solved by S.P.Williams, R.A.Reid, M.Convery, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.58 / 2.25
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	132.018, 58.014, 80.442, 90.00, 124.38, 90.00
R / Rfree (%)	23.1 / 28

The binding sites of Zinc atom in the Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery (pdb code 5waw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery, PDB code: 5waw:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn301 b:72.7 occ:1.00 OD1 L:ASN143 2.0 76.8 1.0 O H:HOH403 2.0 44.5 1.0 OD1 L:ASN142 2.0 81.4 1.0 NE2 H:HIS166 2.1 70.9 1.0 CD2 H:HIS166 2.8 66.0 1.0 CG L:ASN142 3.0 78.3 1.0 O L:HOH405 3.1 62.5 1.0 CG L:ASN143 3.1 79.7 1.0 CE1 H:HIS166 3.2 68.6 1.0 ND2 L:ASN142 3.4 84.5 1.0 ND2 L:ASN143 3.8 87.7 1.0 CG H:HIS166 4.1 63.3 1.0 O H:GLY164 4.2 60.3 1.0 ND1 H:HIS166 4.2 67.3 1.0 OG L:SER179 4.3 61.3 1.0 CB L:ASN143 4.4 72.3 1.0 OG1 H:THR185 4.4 54.8 1.0 CB L:ASN142 4.4 72.7 1.0 C H:GLY164 4.6 66.1 1.0 N L:ASN143 4.6 70.2 1.0 CA H:GLY164 4.7 64.4 1.0 CG2 H:THR185 4.9 54.9 1.0 CA L:ASN143 4.9 70.0 1.0 O L:HOH407 5.0 50.2 1.0

Zinc binding site 2 out of 4 in the Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn302 b:97.3 occ:0.50 OE2 L:GLU86 1.7 0.2 1.0 OE2 L:GLU84 2.4 90.8 1.0 CD L:GLU86 2.8 94.2 1.0 CD L:GLU84 3.1 92.5 1.0 CG L:GLU84 3.3 92.9 1.0 OE1 L:GLU86 3.5 91.5 1.0 CB L:GLU84 3.7 90.0 1.0 CG L:GLU86 3.7 92.4 1.0 NH1 L:ARG66 3.9 96.0 1.0 OE1 L:GLU84 4.2 90.3 1.0 CB L:GLU86 4.7 90.8 1.0 CZ L:ARG66 4.8 95.4 1.0

Zinc binding site 3 out of 4 in the Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn303 b:89.5 occ:0.50 CE1 L:HIS194 2.0 0.8 1.0 OD1 L:ASP190 2.0 91.2 1.0 OD2 L:ASP190 2.0 74.7 1.0 NE2 L:HIS194 2.1 0.6 1.0 CG L:ASP190 2.3 79.5 1.0 O L:HOH401 3.0 65.0 1.0 ND1 L:HIS194 3.0 0.9 1.0 CD2 L:HIS194 3.2 0.2 1.0 CG L:HIS194 3.6 0.3 1.0 CB L:ASP190 3.8 71.7 1.0 O L:ASP190 4.1 71.1 1.0 CA L:ASP190 4.4 71.0 1.0 C L:ASP190 4.6 71.7 1.0

Zinc binding site 4 out of 4 in the Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Fcabvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn301 b:99.4 occ:0.50 OD1 H:ASP59 3.0 65.7 1.0 CG H:ASP59 3.8 54.7 1.0 OD2 H:ASP59 3.8 53.4 1.0 CB H:SER57 3.9 62.2 1.0 O H:ILE58 4.0 57.4 1.0 OG H:SER57 4.2 63.4 1.0 CA H:SER57 4.6 61.4 1.0 C H:ILE58 4.6 55.3 1.0 N H:ILE58 4.7 54.4 1.0 C H:SER57 4.9 60.0 1.0

S.P.Williams, R.A.Reid, M.A.Convery. Abvance: Increasing Our Knowledge of Antibody Structural Space to Enable Faster and Better Decision-Making in Antibody Drug Discovery. Not Published.