Atomistry » Zinc » PDB 6go1-6h0v » 6gxb
Atomistry »
  Zinc »
    PDB 6go1-6h0v »
      6gxb »

Zinc in PDB 6gxb: Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13

Enzymatic activity of Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13

All present enzymatic activity of Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13, PDB code: 6gxb was solved by J.Brynda, P.Rezacova, K.Pospisilova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.61 / 1.35
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 41.820, 41.150, 72.010, 90.00, 103.81, 90.00
R / Rfree (%) 11.3 / 15.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13 (pdb code 6gxb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13, PDB code: 6gxb:

Zinc binding site 1 out of 1 in 6gxb

Go back to Zinc Binding Sites List in 6gxb
Zinc binding site 1 out of 1 in the Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase Caix Mimic in Complex with Inhibitor JS13 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:6.5
occ:1.00
O7 A:FF5302 2.0 10.0 1.0
NE2 A:HIS94 2.0 5.9 1.0
ND1 A:HIS119 2.0 6.5 1.0
NE2 A:HIS96 2.0 6.4 1.0
CE1 A:HIS119 2.9 6.7 1.0
N10 A:FF5302 3.0 7.0 1.0
CD2 A:HIS94 3.0 6.6 1.0
CD2 A:HIS96 3.0 6.3 1.0
CE1 A:HIS94 3.0 5.9 1.0
S8 A:FF5302 3.1 8.7 1.0
CE1 A:HIS96 3.1 6.8 1.0
CG A:HIS119 3.1 5.9 1.0
CB A:HIS119 3.6 5.6 1.0
O A:HOH555 3.6 8.5 1.0
OG1 A:THR198 3.8 6.1 1.0
OE1 A:GLU106 3.9 7.7 1.0
NE2 A:HIS119 4.1 7.1 1.0
O6 A:FF5302 4.1 8.9 1.0
ND1 A:HIS94 4.1 7.1 1.0
CG A:HIS94 4.2 6.8 1.0
CG A:HIS96 4.2 6.5 1.0
ND1 A:HIS96 4.2 7.0 1.0
C A:FF5302 4.2 9.2 1.0
CD2 A:HIS119 4.2 6.9 1.0
O A:HOH476 4.7 14.2 1.0
CD A:GLU106 4.9 7.4 1.0
C2 A:FF5302 4.9 8.5 1.0

Reference:

K.Pospisilova, T.Knedlik, J.Brynda, P.Rezacova, P.Sacha, J.Schimer, V.Kral, P.Cigler, V.Navratil, V.Subr, J.Konvalinka. Inhibitor-Polymer Conjugates As A Versatile Tool For Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms Acs Omega V. 4 6746 2019.
ISSN: ESSN 2470-1343
DOI: 10.1021/ACSOMEGA.9B00596
Page generated: Mon Oct 28 22:02:07 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy