Zinc in PDB 5wai: Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex

The structure of Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex, PDB code: 5wai was solved by S.Chen, L.Jiao, X.Liu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.10 / 2.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	95.300, 111.428, 253.254, 90.00, 90.00, 90.00
R / Rfree (%)	17.1 / 21.6

The binding sites of Zinc atom in the Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex (pdb code 5wai). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex, PDB code: 5wai:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:30.3 occ:1.00 NE2 B:HIS471 1.9 23.0 1.0 NE2 B:HIS466 2.0 29.8 1.0 SG B:CYS450 2.2 31.8 1.0 SG B:CYS453 2.3 31.5 1.0 CE1 B:HIS466 2.8 29.1 1.0 CE1 B:HIS471 2.9 22.3 1.0 CD2 B:HIS471 3.0 24.1 1.0 CD2 B:HIS466 3.1 30.6 1.0 CB B:CYS450 3.2 28.4 1.0 CB B:CYS453 3.4 27.8 1.0 N B:CYS453 3.8 29.4 1.0 ND1 B:HIS466 4.0 29.9 1.0 ND1 B:HIS471 4.0 24.0 1.0 CG B:HIS471 4.1 23.4 1.0 CG B:HIS466 4.1 28.9 1.0 CA B:CYS453 4.2 28.4 1.0 CB B:TRP452 4.5 27.5 1.0 CA B:CYS450 4.6 29.5 1.0 C B:TRP452 4.7 34.1 1.0 C B:CYS453 4.8 32.5 1.0 CB B:LEU455 4.9 21.7 1.0 CA B:TRP452 4.9 30.2 1.0 N B:TRP452 5.0 31.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A SUZ12-RBBP4-JARID2-AEBP2 Heterotetrameric Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn1001 b:39.6 occ:1.00 NE2 F:HIS471 1.9 34.7 1.0 NE2 F:HIS466 2.0 33.2 1.0 SG F:CYS450 2.2 38.9 1.0 SG F:CYS453 2.2 34.7 1.0 CD2 F:HIS471 2.9 36.1 1.0 CE1 F:HIS471 3.0 33.9 1.0 CD2 F:HIS466 3.0 34.5 1.0 CE1 F:HIS466 3.0 32.4 1.0 CB F:CYS450 3.4 34.9 1.0 CB F:CYS453 3.5 30.8 1.0 N F:CYS453 3.7 33.1 1.0 CG F:HIS471 4.1 35.2 1.0 ND1 F:HIS471 4.1 35.3 1.0 CG F:HIS466 4.1 32.8 1.0 ND1 F:HIS466 4.1 33.8 1.0 CA F:CYS453 4.1 31.9 1.0 CB F:TRP452 4.4 31.5 1.0 C F:TRP452 4.7 37.5 1.0 CA F:CYS450 4.7 34.6 1.0 CA F:TRP452 4.9 33.3 1.0 C F:CYS453 4.9 38.4 1.0 N F:TRP452 4.9 35.2 1.0 CB F:LEU455 4.9 27.5 1.0

S.Chen, L.Jiao, M.Shubbar, X.Yang, X.Liu. Unique Structural Platforms of SUZ12 Dictate Distinct Classes of PRC2 For Chromatin Binding. Mol. Cell V. 69 840 2018.
ISSN: ISSN 1097-4164
PubMed: 29499137
DOI: 10.1016/J.MOLCEL.2018.01.039