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Zinc in PDB 5unx: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)BenzonitrileEnzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile:
1.14.13.39; Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile, PDB code: 5unx
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5unx:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile
(pdb code 5unx). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile, PDB code: 5unx: Zinc binding site 1 out of 1 in 5unxGo back to Zinc Binding Sites List in 5unx
Zinc binding site 1 out
of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-[(2-Amino-4-Methylquinolin-7-Yl)Methoxy]-5-(2-(Methylamino) Ethyl)Benzonitrile
Mono view Stereo pair view
Reference:
M.A.Cinelli,
H.Li,
G.Chreifi,
T.L.Poulos,
R.B.Silverman.
Nitrile in the Hole: Discovery of A Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. J. Med. Chem. V. 60 3958 2017.
Page generated: Wed Dec 16 11:05:25 2020
ISSN: ISSN 1520-4804 PubMed: 28422508 DOI: 10.1021/ACS.JMEDCHEM.7B00259 |
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