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Zinc in PDB 5ta6: Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor.Enzymatic activity of Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor.
All present enzymatic activity of Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor.:
2.7.11.21; Protein crystallography data
The structure of Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor., PDB code: 5ta6
was solved by
R.J.Skene,
D.J.Hosfield,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor.
(pdb code 5ta6). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor., PDB code: 5ta6: Zinc binding site 1 out of 1 in 5ta6Go back to Zinc Binding Sites List in 5ta6
Zinc binding site 1 out
of 1 in the Crystal Structure of PLK1 in Complex with A Novel 5,6- Dihydroimidazolo[1,5-F]Pteridine Inhibitor.
Mono view Stereo pair view
Reference:
A.Kiryanov,
S.Natala,
B.Jones,
C.Mcbride,
V.Feher,
B.Lam,
Y.Liu,
K.Honda,
N.Uchiyama,
T.Kawamoto,
Y.Hikichi,
L.Zhang,
D.Hosfield,
R.Skene,
H.Zou,
J.Stafford,
X.Cao,
T.Ichikawa.
Structure-Based Design and Sar Development of 5,6-Dihydroimidazolo[1,5-F]Pteridine Derivatives As Novel Polo-Like Kinase-1 Inhibitors. Bioorg. Med. Chem. Lett. V. 27 1311 2017.
Page generated: Wed Dec 16 10:55:22 2020
ISSN: ESSN 1464-3405 PubMed: 28169164 DOI: 10.1016/J.BMCL.2016.10.009 |
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