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Zinc in PDB 5ol0: Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide

Enzymatic activity of Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide

All present enzymatic activity of Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide:
2.4.2.31;

Protein crystallography data

The structure of Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide, PDB code: 5ol0 was solved by C.Ronin, F.Ciesielski, P.Ciapetti, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.56 / 1.99
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 66.020, 65.670, 66.620, 90.00, 97.75, 90.00
R / Rfree (%) 16.7 / 22.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide (pdb code 5ol0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide, PDB code: 5ol0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5ol0

Go back to Zinc Binding Sites List in 5ol0
Zinc binding site 1 out of 2 in the Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1001

b:53.7
occ:1.00
 SG A:CYS155 2.3 53.9 1.0
SG A:CYS152 2.3 46.0 1.0
SG A:CYS176 2.3 47.5 1.0
SG A:CYS179 2.4 57.4 1.0
CB A:CYS152 3.1 39.7 1.0
CB A:CYS176 3.1 43.2 1.0
CB A:CYS155 3.3 52.8 1.0
CB A:CYS179 3.4 63.9 1.0
N A:CYS155 3.6 53.3 1.0
N A:CYS179 4.0 66.0 1.0
CA A:CYS155 4.0 52.6 1.0
CA A:CYS179 4.2 59.3 1.0
N A:GLY181 4.3 47.4 1.0
CA A:GLY181 4.5 48.2 1.0
CA A:CYS152 4.6 35.2 1.0
CA A:CYS176 4.6 43.8 1.0
CB A:GLU154 4.6 49.3 1.0
C A:CYS155 4.7 54.0 1.0
CB A:THR178 4.7 65.4 1.0
C A:GLU154 4.7 57.0 1.0
OG1 A:THR157 4.8 55.7 1.0
C A:CYS179 4.8 63.3 1.0
N A:HIS156 4.8 51.4 1.0
O A:HOH1150 4.8 42.6 1.0
N A:GLU154 5.0 48.3 1.0
N A:GLY180 5.0 58.1 1.0
C A:THR178 5.0 75.0 1.0
CA A:GLU154 5.0 50.6 1.0
CB A:THR157 5.0 52.0 1.0

Zinc binding site 2 out of 2 in 5ol0

Go back to Zinc Binding Sites List in 5ol0
Zinc binding site 2 out of 2 in the Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Leishmania Infantum Silent Information Regulator 2 Related Protein 1 (LISIR2RP1) in Complex with Acetylated P53 Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1001

b:58.6
occ:1.00
 SG B:CYS155 2.2 59.0 1.0
SG B:CYS152 2.3 49.6 1.0
SG B:CYS179 2.3 69.0 1.0
SG B:CYS176 2.3 53.0 1.0
CB B:CYS152 3.1 46.0 1.0
CB B:CYS176 3.2 48.4 1.0
CB B:CYS155 3.2 60.3 1.0
CB B:CYS179 3.2 65.5 1.0
N B:CYS155 3.7 53.6 1.0
N B:CYS179 3.9 68.8 1.0
CA B:CYS155 4.0 59.5 1.0
CA B:CYS179 4.1 64.2 1.0
N B:GLY181 4.5 45.0 1.0
CA B:CYS152 4.6 44.5 1.0
C B:CYS155 4.6 59.5 1.0
CB B:THR178 4.6 66.5 1.0
CA B:CYS176 4.7 49.1 1.0
C B:CYS179 4.7 59.5 1.0
CA B:GLY181 4.8 46.3 1.0
N B:HIS156 4.8 56.2 1.0
CB B:GLU154 4.8 58.3 1.0
N B:GLY180 4.9 56.8 1.0
C B:GLU154 4.9 60.5 1.0
CG2 B:THR178 4.9 69.3 1.0
O B:HOH1193 5.0 45.8 1.0
CB B:THR157 5.0 57.1 1.0

Reference:

C.Ronin, D.M.Costa, J.Tavares, J.Faria, F.Ciesielski, P.Ciapetti, T.K.Smith, J.Macdougall, A.Cordeiro-Da-Silva, I.K.Pemberton. The Crystal Structure of the Leishmania Infantum Silent Information Regulator 2 Related Protein 1: Implications to Protein Function and Drug Design. Plos One V. 13 93602 2018.
ISSN: ESSN 1932-6203
PubMed: 29543820
DOI: 10.1371/JOURNAL.PONE.0193602
Page generated: Sun Oct 27 23:40:09 2024

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