Zinc in PDB 5oh1: Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide

The structure of Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide, PDB code: 5oh1 was solved by I.Boichenko, R.Albrecht, A.N.Lupas, B.Hernandez Alvarez, M.D.Hartmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.50 / 1.70
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.831, 60.446, 88.523, 90.00, 90.00, 90.00
R / Rfree (%)	16.6 / 21

The binding sites of Zinc atom in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide (pdb code 5oh1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide, PDB code: 5oh1:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:20.9 occ:1.00 SG A:CYS24 2.3 20.1 1.0 SG A:CYS93 2.3 21.9 1.0 SG A:CYS27 2.3 21.0 1.0 SG A:CYS90 2.4 20.2 1.0 CB A:CYS24 3.1 19.3 1.0 CB A:CYS90 3.1 16.9 1.0 CB A:CYS93 3.3 21.4 1.0 CB A:CYS27 3.4 23.9 1.0 N A:CYS93 3.8 21.0 1.0 N A:CYS27 3.9 22.8 1.0 CA A:CYS93 4.1 22.8 1.0 CA A:CYS27 4.2 24.1 1.0 CB A:GLN29 4.4 21.0 0.5 CB A:SER95 4.5 24.6 1.0 CA A:CYS24 4.5 18.0 1.0 CB A:GLN26 4.6 29.2 1.0 CB A:GLN29 4.6 22.6 0.5 CA A:CYS90 4.6 17.8 1.0 C A:GLN26 4.6 31.1 1.0 CB A:GLN92 4.7 23.4 1.0 C A:CYS93 4.8 23.5 1.0 N A:GLY94 4.9 22.3 1.0 C A:CYS27 4.9 25.3 1.0 C A:GLN92 4.9 21.5 1.0 N A:GLN26 4.9 24.6 1.0 CA A:GLN26 4.9 26.7 1.0 N A:SER95 4.9 21.4 1.0 N A:GLY28 4.9 22.0 1.0 C A:CYS24 5.0 18.8 1.0 N A:GLN29 5.0 21.9 1.0

Zinc binding site 2 out of 3 in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:27.2 occ:1.00 SG B:CYS93 2.3 28.6 1.0 SG B:CYS90 2.3 25.6 1.0 SG B:CYS27 2.4 27.7 1.0 SG B:CYS24 2.4 26.2 1.0 CB B:CYS90 3.1 27.0 1.0 CB B:CYS24 3.2 26.8 1.0 CB B:CYS27 3.3 31.1 1.0 CB B:CYS93 3.3 31.1 1.0 N B:CYS27 3.8 28.1 1.0 N B:CYS93 3.8 27.8 1.0 CA B:CYS27 4.1 27.9 1.0 CA B:CYS93 4.1 29.6 1.0 CB B:GLN92 4.6 27.2 1.0 CB B:GLN29 4.6 27.9 0.5 CA B:CYS90 4.6 22.3 1.0 CB B:GLN26 4.6 35.4 1.0 CA B:CYS24 4.7 22.9 1.0 CB B:SER95 4.7 26.6 1.0 C B:CYS27 4.7 29.5 1.0 C B:GLN26 4.8 30.0 1.0 C B:GLN92 4.8 27.2 1.0 N B:GLY28 4.8 27.5 1.0 C B:CYS93 4.8 29.9 1.0 CB B:GLN29 4.9 28.2 0.5 N B:GLY94 4.9 28.7 1.0 N B:GLN29 5.0 27.4 1.0

Zinc binding site 3 out of 3 in the Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cereblon Isoform 4 From Magnetospirillum Gryphiswaldense in Complex with Aminoglutethimide within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:26.1 occ:1.00 SG C:CYS93 2.3 28.6 1.0 SG C:CYS27 2.3 26.4 1.0 SG C:CYS90 2.3 24.8 1.0 SG C:CYS24 2.3 26.2 1.0 CB C:CYS24 3.1 25.5 1.0 CB C:CYS90 3.2 23.1 1.0 CB C:CYS93 3.3 29.7 1.0 CB C:CYS27 3.4 30.4 1.0 N C:CYS93 3.8 25.6 1.0 N C:CYS27 3.8 28.4 1.0 CA C:CYS93 4.1 26.4 1.0 CA C:CYS27 4.2 32.6 1.0 CB C:GLN29 4.4 22.6 1.0 CB C:SER95 4.6 30.3 1.0 CB C:GLN26 4.6 32.4 1.0 CB C:GLN92 4.6 28.5 1.0 CA C:CYS24 4.6 27.1 1.0 CA C:CYS90 4.6 22.8 1.0 C C:CYS93 4.7 29.5 1.0 N C:GLY28 4.7 28.7 1.0 C C:GLN26 4.8 31.7 1.0 C C:CYS27 4.8 35.6 1.0 C C:GLN92 4.8 26.1 1.0 N C:GLY94 4.8 26.9 1.0 N C:GLN29 4.9 26.2 1.0 N C:SER95 4.9 27.5 1.0

I.Boichenko, K.Bar, S.Deiss, C.Heim, R.Albrecht, A.N.Lupas, B.Hernandez Alvarez, M.D.Hartmann. Chemical Ligand Space of Cereblon. Acs Omega V. 3 11163 2018.
ISSN: ESSN 2470-1343
PubMed: 31459225
DOI: 10.1021/ACSOMEGA.8B00959