Atomistry » Zinc » PDB 5n2z-5nea » 5n3w
Atomistry »
  Zinc »
    PDB 5n2z-5nea »
      5n3w »

Zinc in PDB 5n3w: Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation

Enzymatic activity of Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation

All present enzymatic activity of Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation:
3.3.2.6;

Protein crystallography data

The structure of Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation, PDB code: 5n3w was solved by C.T.Wong, C.M.Low, R.J.Snelgrove, S.A.Hare, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 65.65 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.250, 87.050, 99.960, 90.00, 90.00, 90.00
R / Rfree (%) 23.9 / 28.8

Other elements in 5n3w:

The structure of Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation also contains other interesting chemical elements:

Ytterbium (Yb) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation (pdb code 5n3w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation, PDB code: 5n3w:

Zinc binding site 1 out of 1 in 5n3w

Go back to Zinc Binding Sites List in 5n3w
Zinc binding site 1 out of 1 in the Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of LTA4H Bound to A Selective Inhibitor Against LTB4 Generation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:30.3
occ:1.00
 OXT A:ACT705 1.6 25.6 1.0
OE1 A:GLU318 1.9 21.8 1.0
NE2 A:HIS295 2.1 21.4 1.0
NE2 A:HIS299 2.3 21.1 1.0
C A:ACT705 2.4 24.8 1.0
O A:ACT705 2.5 23.4 1.0
CD A:GLU318 2.6 21.1 1.0
OE2 A:GLU318 2.8 22.1 1.0
CD2 A:HIS295 3.1 19.8 1.0
CE1 A:HIS295 3.1 22.0 1.0
CE1 A:HIS299 3.2 20.5 1.0
CD2 A:HIS299 3.3 20.9 1.0
O A:HOH852 3.4 26.1 0.9
CE2 A:TYR383 3.8 19.8 1.0
CH3 A:ACT705 3.8 22.2 1.0
OH A:TYR383 4.0 26.0 1.0
CG A:GLU318 4.0 22.3 1.0
CG A:HIS295 4.2 20.8 1.0
ND1 A:HIS295 4.2 21.4 1.0
CZ A:TYR383 4.3 22.4 1.0
ND1 A:HIS299 4.3 21.6 1.0
OE1 A:GLU271 4.4 25.3 1.0
CG A:HIS299 4.4 22.6 1.0
OE2 A:GLU271 4.6 24.7 1.0
CD2 A:TYR383 4.7 19.0 1.0
CB A:GLU318 4.8 22.7 1.0
CD A:GLU271 4.8 23.0 1.0
OE2 A:GLU296 4.9 31.5 1.0
CA A:GLU318 4.9 23.1 1.0

Reference:

C.M.Low, S.Akthar, D.F.Patel, S.Loser, C.T.Wong, P.L.Jackson, J.E.Blalock, S.A.Hare, C.M.Lloyd, R.J.Snelgrove. The Development of Novel LTA4H Modulators to Selectively Target LTB4 Generation. Sci Rep V. 7 44449 2017.
ISSN: ESSN 2045-2322
PubMed: 28303931
DOI: 10.1038/SREP44449
Page generated: Sun Oct 27 22:31:39 2024

Last articles

Zn in 9FD2
Zn in 9GUW
Zn in 9GUX
Zn in 9F7C
Zn in 9GUR
Zn in 9F7A
Zn in 9DDE
Zn in 9DBY
Zn in 9EBZ
Zn in 9DGG
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy