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Zinc in PDB 5mw8: Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5

Enzymatic activity of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5

All present enzymatic activity of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5:
2.7.1.158;

Protein crystallography data

The structure of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5, PDB code: 5mw8 was solved by E.Franco-Echevarria, J.Sanz-Aparicio, B.Gonzalez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.99 / 2.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 60.162, 71.495, 61.197, 90.00, 111.37, 90.00
R / Rfree (%) 24.1 / 27.1

Other elements in 5mw8:

The structure of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5 (pdb code 5mw8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5, PDB code: 5mw8:

Zinc binding site 1 out of 1 in 5mw8

Go back to Zinc Binding Sites List in 5mw8
Zinc binding site 1 out of 1 in the Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with Atp and IP5 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn503

b:49.9
occ:1.00
 SG A:CYS159 2.0 43.7 1.0
SG A:CYS181 2.4 37.1 1.0
SG A:CYS291 2.4 48.4 1.0
SG A:CYS162 2.5 40.0 1.0
CB A:CYS291 3.1 51.7 1.0
CB A:CYS181 3.2 36.2 1.0
CB A:CYS162 3.3 38.7 1.0
CB A:CYS159 3.6 41.2 1.0
CA A:CYS181 3.9 35.7 1.0
N A:CYS159 4.1 41.2 1.0
N A:SER294 4.2 60.7 1.0
CB A:ALA293 4.3 56.5 1.0
CA A:CYS159 4.4 40.6 1.0
CA A:CYS162 4.5 37.9 1.0
N A:CYS162 4.5 37.0 1.0
CD A:PRO182 4.6 36.4 1.0
CB A:SER294 4.6 62.4 1.0
CA A:CYS291 4.6 52.9 1.0
C A:ALA293 4.7 58.5 1.0
CA A:SER294 4.7 61.7 1.0
C A:CYS181 4.7 35.9 1.0
CG1 A:VAL158 4.8 44.1 1.0
CA A:ALA293 4.9 56.8 1.0
N A:PRO182 4.9 35.9 1.0
N A:ALA293 4.9 55.9 1.0

Reference:

E.Franco-Echevarria, J.Sanz-Aparicio, C.A.Brearley, J.M.Gonzalez-Rubio, B.Gonzalez. The Crystal Structure of Mammalian Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Reveals A New Zinc-Binding Site and Key Features For Protein Function. J. Biol. Chem. V. 292 10534 2017.
ISSN: ESSN 1083-351X
PubMed: 28450399
DOI: 10.1074/JBC.M117.780395
Page generated: Sun Oct 27 22:21:50 2024

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