Zinc in PDB 5mr8: Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide

The structure of Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide, PDB code: 5mr8 was solved by C.Tallant, P.Savitsky, O.Fedorov, G.Nunez-Alonso, P.Siejka, T.Krojer, E.Williams, V.Srikannathasan, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, S.Muller, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.00 / 1.74
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.885, 57.994, 71.488, 90.00, 90.00, 90.00
R / Rfree (%)	22.7 / 28.6

The binding sites of Zinc atom in the Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide (pdb code 5mr8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide, PDB code: 5mr8:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:41.2 occ:1.00 ND1 A:HIS910 2.1 58.5 1.0 SG A:CYS890 2.3 48.0 1.0 SG A:CYS913 2.3 45.0 1.0 SG A:CYS893 2.3 47.0 1.0 CB A:CYS890 3.0 47.0 1.0 CE1 A:HIS910 3.1 58.8 1.0 CG A:HIS910 3.1 52.0 1.0 CB A:CYS913 3.2 48.4 1.0 CB A:CYS893 3.2 49.6 1.0 CB A:HIS910 3.5 48.0 1.0 N A:CYS893 3.8 47.5 1.0 CA A:CYS893 4.1 49.1 1.0 N A:HIS910 4.1 44.6 1.0 NE2 A:HIS910 4.2 58.5 1.0 CD2 A:HIS910 4.2 57.3 1.0 CA A:HIS910 4.4 46.2 1.0 CA A:CYS890 4.5 46.5 1.0 CA A:CYS913 4.6 38.5 1.0 O C:HOH101 4.6 66.6 1.0 CB A:VAL892 4.7 37.8 1.0 C A:CYS893 4.8 52.3 1.0 N A:GLN894 4.9 51.6 1.0 C A:VAL892 4.9 46.1 1.0 O A:HOH1250 4.9 46.5 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1102 b:64.7 occ:1.00 CB A:CYS905 2.3 82.4 1.0 SG A:CYS928 2.4 54.6 1.0 SG A:CYS931 2.4 78.0 1.0 SG A:CYS902 2.6 66.1 1.0 SG A:CYS905 3.1 84.0 1.0 CB A:CYS931 3.3 67.3 1.0 CB A:CYS902 3.4 72.1 1.0 CB A:CYS928 3.5 48.9 1.0 CA A:CYS905 3.5 83.2 1.0 N A:CYS905 3.6 78.0 1.0 N A:CYS928 3.8 54.2 1.0 N A:CYS931 4.0 58.4 1.0 CA A:CYS928 4.1 50.8 1.0 CA A:CYS931 4.3 62.6 1.0 C A:LYS904 4.5 84.7 1.0 C A:CYS928 4.5 52.0 1.0 O A:CYS928 4.6 55.0 1.0 CB A:PHE930 4.6 52.0 1.0 C A:CYS905 4.6 79.5 1.0 C A:PHE930 4.8 55.2 1.0 CA A:CYS902 4.9 70.8 1.0 C A:ILE927 4.9 59.0 1.0 O A:CYS905 5.0 77.8 1.0

C.Tallant, P.Savitsky, O.Fedorov, G.Nunez-Alonso, P.Siejka, T.Krojer, E.Williams, V.Srikannathasan, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, S.Muller, S.Knapp. Crystal Structure of TRIM33 Phd-Bromodomain Isoform B in Complex with H3K9AC Histone Peptide To Be Published.