Zinc in PDB 5mkw: Crystal Structure of the Human ZRANB3 Hnh Domain

The structure of Crystal Structure of the Human ZRANB3 Hnh Domain, PDB code: 5mkw was solved by A.Ariza, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.48 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.841, 67.552, 92.161, 90.00, 90.00, 90.00
R / Rfree (%)	19.2 / 23.6

The binding sites of Zinc atom in the Crystal Structure of the Human ZRANB3 Hnh Domain (pdb code 5mkw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Human ZRANB3 Hnh Domain, PDB code: 5mkw:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Human ZRANB3 Hnh Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Human ZRANB3 Hnh Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:21.7 occ:1.00 SG A:CYS99 2.3 23.2 1.0 SG A:CYS23 2.3 23.9 1.0 SG A:CYS20 2.4 20.0 1.0 SG A:CYS96 2.4 19.6 1.0 CB A:CYS20 3.3 20.1 1.0 CB A:CYS99 3.3 21.9 1.0 CB A:CYS23 3.3 25.1 1.0 CB A:CYS96 3.4 19.2 1.0 O A:HOH413 3.9 33.6 1.0 N A:CYS23 3.9 26.4 1.0 N A:CYS96 3.9 18.4 1.0 CA A:CYS23 4.2 24.7 1.0 CA A:CYS96 4.2 18.8 1.0 N A:CYS99 4.2 20.0 1.0 O A:HOH382 4.3 37.1 1.0 CG2 A:VAL25 4.4 24.2 1.0 CA A:CYS99 4.4 21.1 1.0 CA A:CYS20 4.7 20.1 1.0 CB A:LEU22 4.7 23.4 1.0 O A:CYS96 4.8 17.6 1.0 C A:CYS96 4.8 18.2 1.0 C A:CYS23 4.8 24.0 1.0 C A:LEU22 4.9 27.2 1.0 N A:ASN24 4.9 22.9 1.0 C A:LEU95 5.0 18.4 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Human ZRANB3 Hnh Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Human ZRANB3 Hnh Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:25.7 occ:1.00 SG B:CYS23 2.3 28.4 1.0 SG B:CYS99 2.3 29.4 1.0 SG B:CYS20 2.3 25.1 1.0 SG B:CYS96 2.4 24.3 1.0 CB B:CYS20 3.3 24.2 1.0 CB B:CYS99 3.3 26.7 1.0 CB B:CYS23 3.4 28.8 1.0 CB B:CYS96 3.4 23.5 1.0 N B:CYS23 3.9 31.7 1.0 N B:CYS96 3.9 21.0 1.0 O B:HOH417 4.0 46.2 1.0 CA B:CYS23 4.2 30.3 1.0 CA B:CYS96 4.2 20.6 1.0 N B:CYS99 4.3 25.0 1.0 CG2 B:VAL25 4.3 25.9 1.0 CA B:CYS99 4.4 25.7 1.0 CA B:CYS20 4.7 23.3 1.0 CB B:LEU22 4.7 32.8 1.0 O B:HOH410 4.8 44.7 1.0 O B:CYS96 4.8 18.9 1.0 C B:CYS96 4.8 21.2 1.0 O B:HOH419 4.9 45.8 1.0 C B:CYS23 4.9 30.3 1.0 C B:LEU22 4.9 32.7 1.0 N B:ASN24 5.0 30.5 1.0

M.Sebesta, C.D.O.Cooper, A.Ariza, C.J.Carnie, D.Ahel. Structural Insights Into the Function of ZRANB3 in Replication Stress Response. Nat Commun V. 8 15847 2017.
ISSN: ESSN 2041-1723
PubMed: 28621305
DOI: 10.1038/NCOMMS15847