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Atomistry » Zinc » PDB 5lla-5ls6 » 5llo | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Zinc in PDB 5llo: Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]BenzenesulfonamideEnzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide:
4.2.1.1; Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide, PDB code: 5llo
was solved by
A.Smirnov,
E.Manakova,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5llo:
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide
(pdb code 5llo). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide, PDB code: 5llo: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 5lloGo back to Zinc Binding Sites List in 5llo
Zinc binding site 1 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 5lloGo back to Zinc Binding Sites List in 5llo
Zinc binding site 2 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 5lloGo back to Zinc Binding Sites List in 5llo
Zinc binding site 3 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 5lloGo back to Zinc Binding Sites List in 5llo
Zinc binding site 4 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with 3- [(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hy- Droxyethyl)Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Reference:
A.Smirnov,
A.Zubriene,
E.Manakova,
S.Grazulis,
D.Matulis.
Crystal Structure Correlations with the Intrinsic Thermodynamics of Human Carbonic Anhydrase Inhibitor Binding. Peerj V. 6 E4412 2018.
Page generated: Wed Dec 16 06:29:42 2020
ISSN: ESSN 2167-8359 PubMed: 29503769 DOI: 10.7717/PEERJ.4412 |
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