Zinc in PDB 5ix1: Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide

The structure of Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide, PDB code: 5ix1 was solved by S.Li, J.Du, D.J.Patel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.76 / 2.60
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	111.353, 149.079, 173.473, 90.00, 90.00, 90.00
R / Rfree (%)	21.8 / 23

The structure of Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide (pdb code 5ix1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide, PDB code: 5ix1:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:97.8 occ:1.00 SG A:CYS416 2.0 83.8 1.0 SG A:CYS413 2.2 83.3 1.0 SG A:CYS446 2.6 82.2 1.0 SG A:CYS435 2.8 77.7 1.0 CB A:CYS435 2.8 76.2 1.0 CB A:CYS413 3.1 83.6 1.0 N A:CYS435 3.2 80.0 1.0 CB A:CYS446 3.6 81.4 1.0 CA A:CYS435 3.6 78.5 1.0 CB A:CYS416 3.6 94.0 1.0 CA A:CYS446 3.7 79.7 1.0 N A:CYS416 3.8 89.1 1.0 C A:ALA415 4.1 90.4 1.0 CA A:CYS416 4.3 89.7 1.0 C A:TYR434 4.4 82.5 1.0 N A:CYS446 4.4 79.6 1.0 O A:ALA415 4.5 93.7 1.0 CA A:CYS413 4.5 85.0 1.0 N A:ALA415 4.6 89.2 1.0 CA A:ALA415 4.7 89.9 1.0 CA A:TYR434 4.8 83.7 1.0 CB A:ALA415 4.8 88.4 1.0 C A:CYS435 4.8 76.4 1.0 C A:CYS446 4.9 80.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mouse MORC3 Atpase-Cw Cassette in Complex with Amppnp and H3K4ME3 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:87.9 occ:1.00 SG B:CYS416 2.3 86.1 1.0 SG B:CYS446 2.3 81.2 1.0 SG B:CYS413 2.3 79.9 1.0 SG B:CYS435 2.5 0.5 1.0 CB B:CYS435 2.7 76.1 1.0 CB B:CYS413 3.0 79.1 1.0 CB B:CYS446 3.0 81.8 1.0 CB B:CYS416 3.3 84.9 1.0 CA B:CYS446 3.3 85.9 1.0 N B:CYS435 3.5 79.0 1.0 CA B:CYS435 3.7 78.6 1.0 N B:CYS416 4.0 85.0 1.0 N B:CYS446 4.0 87.1 1.0 CA B:CYS416 4.2 86.3 1.0 CA B:CYS413 4.5 79.5 1.0 C B:CYS446 4.6 86.9 1.0 O B:CYS446 4.7 88.5 1.0 C B:TYR434 4.7 80.5 1.0 C B:ASN445 4.8 86.2 1.0 CG B:LYS418 4.9 86.1 1.0 C B:CYS435 4.9 80.3 1.0 C B:CYS416 4.9 85.9 1.0 NH2 B:ARG420 4.9 78.2 1.0 CB B:ALA415 5.0 85.4 1.0

S.Li, L.Yen, W.A.Pastor, J.B.Johnston, J.Du, C.J.Shew, W.Liu, J.Ho, B.Stender, A.T.Clark, A.L.Burlingame, L.Daxinger, D.J.Patel, S.E.Jacobsen. Mouse MORC3 Is A Ghkl Atpase That Localizes to H3K4ME3 Marked Chromatin Proc.Natl.Acad.Sci.Usa V. 113 E5108 2016.
ISSN: ESSN 1091-6490
PubMed: 27528681
DOI: 10.1073/PNAS.1609709113