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Atomistry » Zinc » PDB 5g2b-5gk8 » 5g4o » |
Zinc in PDB 5g4o: Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083Protein crystallography data
The structure of Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083, PDB code: 5g4o
was solved by
A.C.Joerger,
M.Bauer,
M.G.J.Baud,
J.Spencer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5g4o:
The structure of Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083
(pdb code 5g4o). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083, PDB code: 5g4o: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5g4oGo back to Zinc Binding Sites List in 5g4o
Zinc binding site 1 out
of 2 in the Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 5g4oGo back to Zinc Binding Sites List in 5g4o
Zinc binding site 2 out
of 2 in the Crystal Structure of the P53 Cancer Mutant Y220C in Complex with A Trifluorinated Derivative of the Small Molecule Stabilizer PHIKAN083
Mono view Stereo pair view
Reference:
M.R.Bauer,
R.N.Jones,
M.G.J.Baud,
R.Wilcken,
F.M.Boeckler,
A.R.Fersht,
A.C.Joerger,
J.Spencer.
Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions For the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol. V. 11 2265 2016.
Page generated: Wed Dec 16 06:18:36 2020
ISSN: ISSN 1554-8929 PubMed: 27267810 DOI: 10.1021/ACSCHEMBIO.6B00315 |
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