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Zinc in PDB 5fvo: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine
Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine:
1.14.13.39;
1.14.13.39;
Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine, PDB code: 5fvo
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 51.386 / 2.12 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 44.900, 108.200, 164.290, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.78 / 25.45 |
Other elements in 5fvo:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:
| Iron | (Fe) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine
(pdb code 5fvo). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine, PDB code: 5fvo:
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine, PDB code: 5fvo:
Zinc binding site 1 out of 1 in 5fvo
Go back to
Zinc Binding Sites List in 5fvo
Zinc binding site 1 out
of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(2-(5-(3-Methoxypropylamino)Pyridin-3-Yl) Ethyl)-4-Methylpyridin-2-Amine within 5.0Å range:
|
Reference:
H.Wang,
Y.Qin,
H.Li,
L.J.Roman,
P.Martasek,
T.L.Poulos,
R.B.Silverman.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition By Optimization of the 2-Aminopyridine-Based Scaffold with A Pyridine Linker. J.Med.Chem. V. 59 4913 2016.
ISSN: ISSN 0022-2623
PubMed: 27050842
DOI: 10.1021/ACS.JMEDCHEM.6B00273
Page generated: Sun Oct 27 16:33:33 2024
ISSN: ISSN 0022-2623
PubMed: 27050842
DOI: 10.1021/ACS.JMEDCHEM.6B00273
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