Zinc in PDB 5eu8: Structure of Fipv Main Protease in Complex with Dual Inhibitors

The structure of Structure of Fipv Main Protease in Complex with Dual Inhibitors, PDB code: 5eu8 was solved by F.Wang, C.Chen, X.Liu, K.Yang, X.Xu, H.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.94 / 2.45
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	112.261, 112.261, 102.102, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 24.3

The binding sites of Zinc atom in the Structure of Fipv Main Protease in Complex with Dual Inhibitors (pdb code 5eu8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Fipv Main Protease in Complex with Dual Inhibitors, PDB code: 5eu8:

Zinc binding site 1 out of 1 in the Structure of Fipv Main Protease in Complex with Dual Inhibitors


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Fipv Main Protease in Complex with Dual Inhibitors within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:47.4 occ:0.66 NE2 A:HIS41 2.0 57.1 1.0 OD1 A:ASP186 2.1 55.2 1.0 O A:HOH558 2.2 39.2 1.0 ND1 A:HIS163 2.4 51.9 1.0 CE1 A:HIS41 2.7 66.0 1.0 CG A:ASP186 3.1 59.7 1.0 CD2 A:HIS41 3.1 60.3 1.0 CG A:HIS163 3.2 44.7 1.0 CB A:HIS163 3.2 44.4 1.0 OD2 A:ASP186 3.5 61.1 1.0 CE1 A:HIS163 3.5 47.6 1.0 ND1 A:HIS41 3.8 66.3 1.0 CA A:HIS163 3.9 42.7 1.0 CG A:HIS41 4.0 66.4 1.0 C A:HIS163 4.2 42.9 1.0 CG B:LEU4 4.3 55.3 1.0 CB A:ASP186 4.3 68.2 1.0 CD2 A:HIS163 4.4 46.4 1.0 CA A:ASP186 4.4 65.5 1.0 CE A:MET180 4.5 51.8 1.0 O7 B:PJE5 4.5 82.3 1.0 NE2 A:HIS163 4.6 47.4 1.0 O A:HIS163 4.6 52.8 1.0 N A:LEU164 4.7 42.6 1.0 CD1 B:LEU4 4.7 55.1 1.0 CD2 A:LEU164 4.7 57.5 1.0 O A:ASP186 4.8 68.5 1.0 C A:ASP186 4.8 68.5 1.0

F.Wang, C.Chen, X.Liu, K.Yang, X.Xu, H.Yang. Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors J.Virol. V. 90 1910 2015.
ISSN: ESSN 1098-5514
PubMed: 26656689
DOI: 10.1128/JVI.02685-15