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Zinc in PDB 5efn: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate
Enzymatic activity of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate
All present enzymatic activity of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate:
3.5.1.98;
3.5.1.98;
Protein crystallography data
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate, PDB code: 5efn
was solved by
Y.Hai,
D.W.Christianson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 12.34 / 1.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 54.997, 83.908, 86.903, 90.00, 98.12, 90.00 |
| R / Rfree (%) | 16.2 / 19.4 |
Other elements in 5efn:
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate also contains other interesting chemical elements:
| Potassium | (K) | 4 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate
(pdb code 5efn). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate, PDB code: 5efn:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate, PDB code: 5efn:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 5efn
Go back to
Zinc Binding Sites List in 5efn
Zinc binding site 1 out
of 2 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate within 5.0Å range:
|
Zinc binding site 2 out of 2 in 5efn
Go back to
Zinc Binding Sites List in 5efn
Zinc binding site 2 out
of 2 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 (H574A) in Complex with Histone H4 LYS6 Tripeptide Substrate within 5.0Å range:
|
Reference:
Y.Hai,
D.W.Christianson.
Histone Deacetylase 6 Structure and Molecular Basis of Catalysis and Inhibition. Nat.Chem.Biol. V. 12 741 2016.
ISSN: ESSN 1552-4469
PubMed: 27454933
DOI: 10.1038/NCHEMBIO.2134
Page generated: Wed Dec 16 06:09:45 2020
ISSN: ESSN 1552-4469
PubMed: 27454933
DOI: 10.1038/NCHEMBIO.2134
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