Zinc in PDB 5dy5: Crystal Structure of Human SIRT2 in Complex with A Sirreal Probe Fragment

The structure of Crystal Structure of Human SIRT2 in Complex with A Sirreal Probe Fragment, PDB code: 5dy5 was solved by T.Rumpf, S.Gerhardt, O.Einsle, M.Jung, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.85 / 1.95
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	98.150, 53.360, 83.590, 90.00, 114.01, 90.00
R / Rfree (%)	19 / 20.5

The binding sites of Zinc atom in the Crystal Structure of Human SIRT2 in Complex with A Sirreal Probe Fragment (pdb code 5dy5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human SIRT2 in Complex with A Sirreal Probe Fragment, PDB code: 5dy5:

Zinc binding site 1 out of 1 in the Crystal Structure of Human SIRT2 in Complex with A Sirreal Probe Fragment


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human SIRT2 in Complex with A Sirreal Probe Fragment within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:24.0 occ:1.00 SG A:CYS200 2.3 25.2 1.0 SG A:CYS221 2.3 24.5 1.0 SG A:CYS195 2.3 22.8 1.0 SG A:CYS224 2.3 24.5 1.0 CB A:CYS221 3.1 25.1 1.0 CB A:CYS200 3.2 25.6 1.0 CB A:CYS195 3.2 22.6 1.0 CB A:CYS224 3.5 25.6 1.0 N A:CYS224 3.9 26.6 1.0 CA A:CYS224 4.2 26.2 1.0 CB A:ASP223 4.4 28.8 1.0 CB A:HIS202 4.5 27.7 1.0 O A:HOH723 4.5 41.0 1.0 CA A:CYS200 4.6 26.0 1.0 CA A:CYS221 4.6 25.7 1.0 N A:HIS202 4.6 26.6 1.0 CA A:CYS195 4.6 22.2 1.0 CB A:SER197 4.7 25.4 1.0 N A:ARG201 4.7 26.6 1.0 CB A:SER226 4.8 24.1 1.0 C A:ASP223 4.8 27.7 1.0 C A:CYS224 4.8 26.1 1.0 C A:CYS200 4.9 26.2 1.0 N A:GLN225 5.0 26.1 1.0 CA A:ASP223 5.0 28.3 1.0

M.Schiedel, T.Rumpf, B.Karaman, A.Lehotzky, S.Gerhardt, J.Ovadi, W.Sippl, O.Einsle, M.Jung. Structure-Based Development of An Affinity Probe For Sirtuin 2. Angew.Chem.Int.Ed.Engl. V. 55 2252 2016.
ISSN: ESSN 1521-3773
PubMed: 26748890
DOI: 10.1002/ANIE.201509843