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Zinc in PDB 5drs: Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]BenzenesulfonamideEnzymatic activity of Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide:
4.2.1.1; Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide, PDB code: 5drs
was solved by
A.Smirnov,
E.Manakova,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5drs:
The structure of Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
(pdb code 5drs). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide, PDB code: 5drs: Zinc binding site 1 out of 1 in 5drsGo back to Zinc Binding Sites List in 5drs
Zinc binding site 1 out
of 1 in the Crystal Structure of Human Carbonic Anhydraseisozyme II with 3-[(1S)- 2,3-Dihydro-1H-Inden-1-Ylamino]-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Reference:
A.Zubriene,
A.Smirnov,
V.Dudutiene,
D.D.Timm,
J.Matuliene,
V.Michailoviene,
A.Zaksauskas,
E.Manakova,
S.Grazulis,
D.Matulis.
Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases. Chemmedchem V. 12 161 2017.
Page generated: Wed Dec 16 06:08:45 2020
ISSN: ESSN 1860-7187 PubMed: 28001003 DOI: 10.1002/CMDC.201600509 |
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