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Zinc in PDB 5cvn: WDR48 (2-580):USP46~Ubiquitin Ternary Complex

Enzymatic activity of WDR48 (2-580):USP46~Ubiquitin Ternary Complex

All present enzymatic activity of WDR48 (2-580):USP46~Ubiquitin Ternary Complex:
3.4.19.12;

Protein crystallography data

The structure of WDR48 (2-580):USP46~Ubiquitin Ternary Complex, PDB code: 5cvn was solved by S.F.Harris, J.Yin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.36 / 3.36
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.437, 154.189, 182.854, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 22.2

Zinc Binding Sites:

The binding sites of Zinc atom in the WDR48 (2-580):USP46~Ubiquitin Ternary Complex (pdb code 5cvn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the WDR48 (2-580):USP46~Ubiquitin Ternary Complex, PDB code: 5cvn:

Zinc binding site 1 out of 1 in 5cvn

Go back to Zinc Binding Sites List in 5cvn
Zinc binding site 1 out of 1 in the WDR48 (2-580):USP46~Ubiquitin Ternary Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of WDR48 (2-580):USP46~Ubiquitin Ternary Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn900

b:88.5
occ:1.00
SG B:CYS182 2.2 77.1 1.0
SG B:CYS229 2.2 77.1 1.0
SG B:CYS185 2.3 80.3 1.0
SG B:CYS232 2.4 82.1 1.0
CB B:CYS229 3.1 71.0 1.0
CB B:CYS182 3.1 71.1 1.0
CB B:CYS232 3.3 77.5 1.0
CB B:CYS185 3.3 80.3 1.0
N B:CYS185 3.7 80.1 1.0
OG1 B:THR231 3.9 76.8 1.0
N B:CYS232 4.0 78.5 1.0
CA B:CYS185 4.1 81.3 1.0
CA B:CYS232 4.2 78.8 1.0
CA B:CYS182 4.5 70.0 1.0
CA B:CYS229 4.5 68.9 1.0
CB B:ASN184 4.6 73.9 1.0
C B:ASN184 4.7 85.0 1.0
N B:ASN184 4.9 75.2 1.0
C B:CYS182 4.9 75.4 1.0
OG1 B:THR187 4.9 80.0 1.0
C B:CYS185 4.9 85.7 1.0
C B:THR231 4.9 83.8 1.0
CA B:ASN184 4.9 77.4 1.0
N B:GLU186 5.0 79.7 1.0

Reference:

J.Yin, A.J.Schoeffler, K.Wickliffe, K.Newton, M.A.Starovasnik, E.C.Dueber, S.F.Harris. Structural Insights Into Wd-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure V. 23 2043 2015.
ISSN: ISSN 0969-2126
PubMed: 26388029
DOI: 10.1016/J.STR.2015.08.010
Page generated: Wed Dec 16 06:07:30 2020

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