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Zinc in PDB 5a3c: Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad

Enzymatic activity of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad

All present enzymatic activity of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad:
2.4.2.30;

Protein crystallography data

The structure of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad, PDB code: 5a3c was solved by J.G.M.Rack, R.Morra, E.Barkauskaite, R.Kraehenbuehl, A.Ariza, Y.Qu, M.Ortmayer, O.Leidecker, D.R.Cameron, I.Matic, A.Y.Peleg, D.Leys, A.Traven, I.Ahel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.82 / 2.03
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 33.880, 41.480, 51.260, 99.55, 93.61, 92.98
R / Rfree (%) 17.559 / 23.33

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad (pdb code 5a3c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad, PDB code: 5a3c:

Zinc binding site 1 out of 1 in 5a3c

Go back to Zinc Binding Sites List in 5a3c
Zinc binding site 1 out of 1 in the Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Nad within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1293

b:25.5
occ:1.00
 SG A:CYS180 2.1 27.0 1.0
SG A:CYS183 2.3 26.9 1.0
SG A:CYS145 2.3 23.9 1.0
SG A:CYS149 2.4 28.3 1.0
CB A:CYS180 3.1 29.4 1.0
CB A:CYS183 3.2 27.7 1.0
CB A:CYS145 3.3 21.7 1.0
CB A:CYS149 3.3 28.5 1.0
N A:CYS183 3.7 29.9 1.0
CA A:CYS183 4.0 28.8 1.0
ND1 A:HIS150 4.2 27.3 1.0
N A:CYS149 4.2 30.7 1.0
CA A:CYS149 4.3 29.6 1.0
CE1 A:HIS150 4.4 27.2 1.0
CB A:GLU182 4.4 36.1 1.0
CA A:CYS180 4.6 29.8 1.0
CA A:CYS145 4.6 20.7 1.0
C A:CYS183 4.7 29.0 1.0
C A:GLU182 4.7 33.0 1.0
N A:GLU184 4.8 30.0 1.0
CB A:ALA185 4.9 24.9 1.0
N A:GLU182 4.9 33.2 1.0
CA A:GLU182 4.9 33.8 1.0
CB A:GLN147 4.9 33.5 1.0
N A:ALA185 4.9 25.8 1.0
C A:CYS180 5.0 30.9 1.0

Reference:

J.G.Rack, R.Morra, E.Barkauskaite, R.Kraehenbuehl, A.Ariza, Y.Qu, M.Ortmayer, O.Leidecker, D.R.Cameron, I.Matic, A.Y.Peleg, D.Leys, A.Traven, I.Ahel. Identification of A Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens. Mol.Cell V. 59 309 2015.
ISSN: ISSN 1097-2765
PubMed: 26166706
DOI: 10.1016/J.MOLCEL.2015.06.013
Page generated: Sun Oct 27 12:37:42 2024

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