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Zinc in PDB 5a3b: Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose

Enzymatic activity of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose

All present enzymatic activity of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose:
2.4.2.30;

Protein crystallography data

The structure of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose, PDB code: 5a3b was solved by J.G.M.Rack, R.Morra, E.Barkauskaite, R.Kraehenbuehl, A.Ariza, Y.Qu, M.Ortmayer, O.Leidecker, D.R.Cameron, I.Matic, A.Y.Peleg, D.Leys, A.Traven, I.Ahel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.39 / 1.90
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 33.943, 41.521, 51.253, 99.76, 93.40, 92.66
R / Rfree (%) 16.318 / 21.577

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose (pdb code 5a3b). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose, PDB code: 5a3b:

Zinc binding site 1 out of 1 in 5a3b

Go back to Zinc Binding Sites List in 5a3b
Zinc binding site 1 out of 1 in the Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Adp-Ribosylating Sirtuin (Sirtm) From Streptococcus Pyogenes in Complex with Adp-Ribose within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1293

b:16.9
occ:1.00
 SG A:CYS180 2.2 17.8 1.0
SG A:CYS183 2.2 22.3 1.0
SG A:CYS149 2.3 18.9 1.0
SG A:CYS145 2.4 14.8 1.0
CB A:CYS180 3.1 17.4 1.0
CB A:CYS145 3.2 12.8 1.0
CB A:CYS149 3.2 20.1 1.0
CB A:CYS183 3.2 22.5 1.0
N A:CYS183 3.7 24.4 1.0
CA A:CYS183 4.0 22.8 1.0
N A:CYS149 4.2 20.7 1.0
ND1 A:HIS150 4.3 17.9 1.0
CA A:CYS149 4.3 20.9 1.0
CB A:GLU182 4.4 28.3 1.0
CE1 A:HIS150 4.5 17.5 1.0
CA A:CYS145 4.5 11.5 1.0
CA A:CYS180 4.6 18.0 1.0
C A:GLU182 4.7 26.5 1.0
C A:CYS183 4.7 22.3 1.0
CB A:ALA185 4.8 15.0 1.0
N A:GLU184 4.9 21.8 1.0
CA A:GLU182 4.9 27.2 1.0
N A:GLU182 4.9 27.3 1.0
N A:ALA185 4.9 16.3 1.0
O A:HOH2130 4.9 31.8 1.0
C A:CYS180 5.0 20.7 1.0
C A:CYS149 5.0 20.6 1.0

Reference:

J.G.Rack, R.Morra, E.Barkauskaite, R.Kraehenbuehl, A.Ariza, Y.Qu, M.Ortmayer, O.Leidecker, D.R.Cameron, I.Matic, A.Y.Peleg, D.Leys, A.Traven, I.Ahel. Identification of A Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens. Mol.Cell V. 59 309 2015.
ISSN: ISSN 1097-2765
PubMed: 26166706
DOI: 10.1016/J.MOLCEL.2015.06.013
Page generated: Sun Oct 27 12:37:41 2024

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