Atomistry » Zinc » PDB 4zuq-5a0r » 4zzi
Atomistry »
  Zinc »
    PDB 4zuq-5a0r »
      4zzi »

Zinc in PDB 4zzi: SIRT1/Activator/Inhibitor Complex

Protein crystallography data

The structure of SIRT1/Activator/Inhibitor Complex, PDB code: 4zzi was solved by H.Dai, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.98 / 2.73
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 122.150, 122.150, 104.920, 90.00, 90.00, 120.00
R / Rfree (%) 19.1 / 23.5

Other elements in 4zzi:

The structure of SIRT1/Activator/Inhibitor Complex also contains other interesting chemical elements:

Fluorine (F) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the SIRT1/Activator/Inhibitor Complex (pdb code 4zzi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the SIRT1/Activator/Inhibitor Complex, PDB code: 4zzi:

Zinc binding site 1 out of 1 in 4zzi

Go back to Zinc Binding Sites List in 4zzi
Zinc binding site 1 out of 1 in the SIRT1/Activator/Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SIRT1/Activator/Inhibitor Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn703

b:0.2
occ:1.00
SG A:CYS398 2.4 0.5 1.0
SG A:CYS371 2.4 0.1 1.0
SG A:CYS374 2.4 0.1 1.0
SG A:CYS395 2.6 0.4 1.0
CB A:CYS395 2.9 0.3 1.0
CB A:CYS371 3.1 0.5 1.0
CB A:CYS398 3.5 0.8 1.0
CB A:CYS374 3.5 0.9 1.0
N A:CYS374 3.7 0.4 1.0
CA A:CYS374 4.2 0.5 1.0
N A:CYS398 4.2 0.2 1.0
CB A:ILE373 4.3 0.5 1.0
CA A:CYS398 4.3 0.1 1.0
CA A:CYS395 4.4 1.0 1.0
CA A:CYS371 4.6 0.7 1.0
CB A:ALA405 4.6 0.6 1.0
C A:ILE373 4.8 0.4 1.0
CA A:ALA405 4.8 0.9 1.0
C A:CYS374 4.8 0.1 1.0
N A:ILE373 4.9 0.3 1.0
N A:LYS375 4.9 0.2 1.0
CA A:ILE373 4.9 0.0 1.0

Reference:

H.Dai, A.W.Case, T.V.Riera, T.Considine, J.E.Lee, Y.Hamuro, H.Zhao, Y.Jiang, S.M.Sweitzer, B.Pietrak, B.Schwartz, C.A.Blum, J.S.Disch, R.Caldwell, B.Szczepankiewicz, C.Oalmann, P.Yee Ng, B.H.White, R.Casaubon, R.Narayan, K.Koppetsch, F.Bourbonais, B.Wu, J.Wang, D.Qian, F.Jiang, C.Mao, M.Wang, E.Hu, J.C.Wu, R.B.Perni, G.P.Vlasuk, J.L.Ellis. Crystallographic Structure of A Small Molecule SIRT1 Activator-Enzyme Complex. Nat Commun V. 6 7645 2015.
ISSN: ESSN 2041-1723
PubMed: 26134520
DOI: 10.1038/NCOMMS8645
Page generated: Wed Dec 16 06:00:58 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy