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Zinc in PDB 4zzh: SIRT1/Activator Complex

Protein crystallography data

The structure of SIRT1/Activator Complex, PDB code: 4zzh was solved by H.Dai, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.67 / 3.10
Space group I 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 99.190, 111.640, 132.520, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / 23.8

Other elements in 4zzh:

The structure of SIRT1/Activator Complex also contains other interesting chemical elements:

Fluorine (F) 3 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the SIRT1/Activator Complex (pdb code 4zzh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the SIRT1/Activator Complex, PDB code: 4zzh:

Zinc binding site 1 out of 1 in 4zzh

Go back to Zinc Binding Sites List in 4zzh
Zinc binding site 1 out of 1 in the SIRT1/Activator Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of SIRT1/Activator Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:0.6
occ:1.00
SG A:CYS371 2.3 0.0 1.0
SG A:CYS395 2.5 0.6 1.0
SG A:CYS398 2.5 0.8 1.0
SG A:CYS374 2.7 0.1 1.0
CB A:CYS395 3.1 0.6 1.0
CB A:CYS371 3.3 0.6 1.0
CB A:CYS398 3.3 0.3 1.0
N A:CYS374 3.5 0.7 1.0
CB A:CYS374 3.7 0.8 1.0
CB A:ILE373 4.0 0.9 1.0
CA A:CYS374 4.2 0.8 1.0
CB A:ALA405 4.2 0.5 1.0
N A:CYS398 4.3 0.3 1.0
CA A:ALA405 4.3 0.8 1.0
CA A:CYS398 4.4 0.8 1.0
C A:ILE373 4.5 0.2 1.0
CG2 A:ILE373 4.6 0.2 1.0
CA A:CYS395 4.6 0.2 1.0
CA A:ILE373 4.6 0.5 1.0
N A:ILE373 4.7 0.3 1.0
CA A:CYS371 4.7 0.8 1.0
C A:ALA405 4.8 0.5 1.0
O A:ALA405 4.9 0.1 1.0
C A:CYS374 4.9 0.9 1.0
N A:LYS375 4.9 0.2 1.0
CG1 A:ILE373 4.9 0.5 1.0

Reference:

H.Dai, A.W.Case, T.V.Riera, T.Considine, J.E.Lee, Y.Hamuro, H.Zhao, Y.Jiang, S.M.Sweitzer, B.Pietrak, B.Schwartz, C.A.Blum, J.S.Disch, R.Caldwell, B.Szczepankiewicz, C.Oalmann, P.Yee Ng, B.H.White, R.Casaubon, R.Narayan, K.Koppetsch, F.Bourbonais, B.Wu, J.Wang, D.Qian, F.Jiang, C.Mao, M.Wang, E.Hu, J.C.Wu, R.B.Perni, G.P.Vlasuk, J.L.Ellis. Crystallographic Structure of A Small Molecule SIRT1 Activator-Enzyme Complex. Nat Commun V. 6 7645 2015.
ISSN: ESSN 2041-1723
PubMed: 26134520
DOI: 10.1038/NCOMMS8645
Page generated: Sun Oct 27 12:13:25 2024

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