Zinc in PDB 4r7e: Structure of BRE1 Ring Domain

The structure of Structure of BRE1 Ring Domain, PDB code: 4r7e was solved by P.Kumar, C.Wolberger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.16 / 2.25
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	56.765, 56.765, 134.858, 90.00, 90.00, 120.00
R / Rfree (%)	22.1 / 24.7

The binding sites of Zinc atom in the Structure of BRE1 Ring Domain (pdb code 4r7e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of BRE1 Ring Domain, PDB code: 4r7e:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of BRE1 Ring Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of BRE1 Ring Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:77.1 occ:1.00 ND1 A:HIS665 2.0 77.7 1.0 SG A:CYS663 2.2 70.8 1.0 SG A:CYS683 2.4 74.6 1.0 SG A:CYS686 2.5 77.4 1.0 CE1 A:HIS665 2.9 76.3 1.0 CG A:HIS665 3.0 72.4 1.0 CB A:CYS663 3.1 72.6 1.0 CB A:CYS683 3.2 77.2 1.0 CB A:HIS665 3.4 68.5 1.0 CB A:CYS686 3.7 76.9 1.0 N A:CYS686 4.0 77.8 1.0 NE2 A:HIS665 4.1 75.1 1.0 CD2 A:HIS665 4.1 71.8 1.0 N A:HIS665 4.4 68.6 1.0 CA A:CYS663 4.4 71.0 1.0 CA A:CYS686 4.4 78.9 1.0 CB A:THR685 4.5 77.3 1.0 CA A:HIS665 4.6 68.4 1.0 C A:CYS663 4.6 73.0 1.0 O A:CYS663 4.6 76.2 1.0 CA A:CYS683 4.7 79.1 1.0 C A:THR685 4.9 78.1 1.0 N A:THR685 5.0 79.6 1.0 C A:CYS686 5.0 79.9 1.0

Zinc binding site 2 out of 2 in the Structure of BRE1 Ring Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of BRE1 Ring Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn802 b:68.2 occ:1.00 SG A:CYS671 2.3 68.6 1.0 SG A:CYS668 2.3 67.4 1.0 SG A:CYS648 2.3 63.9 1.0 SG A:CYS651 2.4 72.2 1.0 CB A:CYS648 3.1 66.3 1.0 CB A:CYS671 3.2 68.8 1.0 CB A:CYS651 3.3 68.4 1.0 CB A:CYS668 3.5 66.3 1.0 N A:CYS651 3.6 71.7 1.0 N A:CYS668 4.1 65.2 1.0 CA A:CYS651 4.1 70.6 1.0 N A:CYS671 4.2 68.2 1.0 CA A:CYS668 4.3 64.2 1.0 CA A:CYS671 4.3 71.3 1.0 CB A:LEU650 4.3 70.8 1.0 CA A:CYS648 4.5 69.0 1.0 C A:LEU650 4.6 68.6 1.0 O A:CYS668 4.7 61.7 1.0 C A:CYS668 4.8 63.1 1.0 N A:LEU650 4.8 72.7 1.0 CA A:LEU650 4.8 70.0 1.0 CB A:ASN654 4.8 73.1 1.0 ND2 A:ASN654 4.9 70.8 1.0 C A:CYS648 4.9 64.1 1.0

P.Kumar, C.Wolberger. Structure of the Yeast BRE1 Ring Domain. Proteins 2015.
ISSN: ESSN 1097-0134
PubMed: 25864391
DOI: 10.1002/PROT.24812