Zinc in PDB 4oc1: X-Ray Structure of of Human Glutamate Carboxypeptidase II (Gcpii) in A Complex with Coibzl, A Urea-Based Inhibitor (2S)-2-[({(1S)-1-Carboxy- 2-[(2S)-Oxiran-2-Yl]Ethyl}Carbamoyl)Amino]-6-[(4-Iodobenzoyl) Amino]Hexanoic Acid

Enzymatic activity of X-Ray Structure of of Human Glutamate Carboxypeptidase II (Gcpii) in A Complex with Coibzl, A Urea-Based Inhibitor (2S)-2-[({(1S)-1-Carboxy- 2-[(2S)-Oxiran-2-Yl]Ethyl}Carbamoyl)Amino]-6-[(4-Iodobenzoyl) Amino]Hexanoic Acid

Protein crystallography data

Other elements in 4oc1:

Zinc Binding Sites:

Zinc binding site 1 out of 2 in 4oc1

Zinc Binding Sites List in 4oc1

Zinc binding site 1 out of 2 in the X-Ray Structure of of Human Glutamate Carboxypeptidase II (Gcpii) in A Complex with Coibzl, A Urea-Based Inhibitor (2S)-2-[({(1S)-1-Carboxy- 2-[(2S)-Oxiran-2-Yl]Ethyl}Carbamoyl)Amino]-6-[(4-Iodobenzoyl) Amino]Hexanoic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of X-Ray Structure of of Human Glutamate Carboxypeptidase II (Gcpii) in A Complex with Coibzl, A Urea-Based Inhibitor (2S)-2-[({(1S)-1-Carboxy- 2-[(2S)-Oxiran-2-Yl]Ethyl}Carbamoyl)Amino]-6-[(4-Iodobenzoyl) Amino]Hexanoic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn814 b:19.4 occ:1.00 O A:HOH1427 2.0 18.0 1.0 NE2 A:HIS553 2.0 17.4 1.0 OE2 A:GLU425 2.1 17.8 1.0 OD2 A:ASP387 2.1 20.0 1.0 OE1 A:GLU425 2.5 16.9 1.0 OAC A:2QS818 2.5 16.0 0.6 CD A:GLU425 2.6 16.7 1.0 CE1 A:HIS553 2.9 16.9 1.0 CG A:ASP387 3.0 19.3 1.0 CD2 A:HIS553 3.1 16.8 1.0 OAC A:2QS818 3.2 20.1 0.4 CAX A:2QS818 3.3 15.6 0.6 ZN A:ZN815 3.3 18.9 1.0 OD1 A:ASP387 3.3 18.0 1.0 NAT A:2QS818 3.8 14.2 0.6 CBD A:2QS818 3.9 13.8 0.6 CAX A:2QS818 3.9 20.7 0.4 CE1 A:TYR552 4.0 17.6 1.0 ND1 A:HIS553 4.1 17.3 1.0 N A:2QS818 4.1 16.2 0.6 OE1 A:GLU424 4.1 18.4 1.0 O A:HOH916 4.2 19.8 1.0 CG A:GLU425 4.2 16.1 1.0 CG A:HIS553 4.2 17.2 1.0 CB A:ASP387 4.3 18.9 1.0 OH A:TYR552 4.4 19.8 1.0 CA A:2QS818 4.4 18.3 0.6 CAW A:2QS818 4.5 19.9 0.6 NAT A:2QS818 4.5 18.8 0.4 NE2 A:HIS377 4.5 16.1 1.0 CZ A:TYR552 4.6 20.1 1.0 CBD A:2QS818 4.6 17.2 0.4 N A:2QS818 4.7 19.9 0.4 CD1 A:TRP381 4.7 20.1 1.0 CE1 A:HIS377 4.7 15.4 1.0 OAB A:2QS818 4.8 20.5 0.6 NE1 A:TRP381 4.8 18.0 1.0 OD2 A:ASP453 4.8 20.6 1.0 CA A:2QS818 4.9 21.4 0.4 OAB A:2QS818 4.9 22.7 0.4 CD1 A:TYR552 5.0 19.6 1.0

Zinc binding site 2 out of 2 in 4oc1

Zinc Binding Sites List in 4oc1

Zinc binding site 2 out of 2 in the X-Ray Structure of of Human Glutamate Carboxypeptidase II (Gcpii) in A Complex with Coibzl, A Urea-Based Inhibitor (2S)-2-[({(1S)-1-Carboxy- 2-[(2S)-Oxiran-2-Yl]Ethyl}Carbamoyl)Amino]-6-[(4-Iodobenzoyl) Amino]Hexanoic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of X-Ray Structure of of Human Glutamate Carboxypeptidase II (Gcpii) in A Complex with Coibzl, A Urea-Based Inhibitor (2S)-2-[({(1S)-1-Carboxy- 2-[(2S)-Oxiran-2-Yl]Ethyl}Carbamoyl)Amino]-6-[(4-Iodobenzoyl) Amino]Hexanoic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn815 b:18.9 occ:1.00 OD2 A:ASP453 1.9 20.6 1.0 O A:HOH1427 1.9 18.0 1.0 NE2 A:HIS377 2.0 16.1 1.0 OD1 A:ASP387 2.0 18.0 1.0 CG A:ASP453 2.7 21.2 1.0 OD1 A:ASP453 2.8 25.0 1.0 CG A:ASP387 2.9 19.3 1.0 CE1 A:HIS377 3.0 15.4 1.0 CD2 A:HIS377 3.0 15.5 1.0 OD2 A:ASP387 3.2 20.0 1.0 ZN A:ZN814 3.3 19.4 1.0 OE2 A:GLU425 3.6 17.8 1.0 OE1 A:GLU424 3.7 18.4 1.0 CD A:GLU424 4.1 18.2 1.0 ND1 A:HIS377 4.1 17.4 1.0 CB A:ASP453 4.2 19.1 1.0 CG A:HIS377 4.2 16.0 1.0 CB A:ASP387 4.2 18.9 1.0 ND2 A:ASN519 4.2 17.3 1.0 OE2 A:GLU424 4.3 20.1 1.0 CB A:PRO388 4.3 17.1 1.0 CD A:GLU425 4.3 16.7 1.0 CAX A:2QS818 4.4 15.6 0.6 N A:2QS818 4.4 16.2 0.6 CA A:PRO388 4.5 16.9 1.0 CA A:ASP387 4.6 17.4 1.0 OAC A:2QS818 4.6 16.0 0.6 C A:ASP387 4.6 18.0 1.0 N A:PRO388 4.6 17.6 1.0 OE1 A:GLU425 4.7 16.9 1.0 CA A:2QS818 4.7 18.3 0.6 O A:HOH1406 4.8 29.9 1.0 OXT A:2QS818 4.8 20.5 0.6 OG A:SER454 4.8 22.6 1.0 NAT A:2QS818 4.8 14.2 0.6 C A:2QS818 4.8 19.3 0.6

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