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Atomistry » Zinc » PDB 4ngq-4ntm » 4npv » |
Zinc in PDB 4npv: Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine)Enzymatic activity of Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine)
All present enzymatic activity of Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine):
3.1.4.17; Protein crystallography data
The structure of Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine), PDB code: 4npv
was solved by
J.Pandit,
A.Evdomikov,
M.Mansour,
S.Simons,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4npv:
The structure of Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine)
(pdb code 4npv). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine), PDB code: 4npv: Zinc binding site 1 out of 1 in 4npvGo back to Zinc Binding Sites List in 4npv
Zinc binding site 1 out
of 1 in the Crystal Structure of Human PDE1B Bound to Inhibitor 7A (6,7,8- Trimethoxy-N-(Pentan-3-Yl)Quinazolin-4-Amine)
Mono view Stereo pair view
Reference:
J.M.Humphrey,
E.X.Yang,
C.W.Am Ende,
E.P.Arnold,
J.L.Head,
S.Jenkinsonb,
L.A.Lebel,
S.Liras,
J.Pandit,
B.Samas,
F.Vajdos,
S.P.Simons,
A.Evdokimova,
M.Mansour,
F.S.Menniti.
Small-Molecule Phosphodiesterase Probes: Discovery of Potent and Selective Cns-Penetrable Quinazoline Inhibitors of PDE1 Medchemcomm 2014.
Page generated: Wed Dec 16 05:37:24 2020
ISSN: ESSN 2040-2511 DOI: 10.1039/C4MD00113C |
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