Zinc in PDB 4n90: Crystal Structure of Ternary Complex of Trail, DR5, and Fab Fragment From A DR5 Agonist Antibody

The structure of Crystal Structure of Ternary Complex of Trail, DR5, and Fab Fragment From A DR5 Agonist Antibody, PDB code: 4n90 was solved by X.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 3.30
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	152.006, 152.006, 613.155, 90.00, 90.00, 120.00
R / Rfree (%)	22.9 / 28.6

The binding sites of Zinc atom in the Crystal Structure of Ternary Complex of Trail, DR5, and Fab Fragment From A DR5 Agonist Antibody (pdb code 4n90). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Ternary Complex of Trail, DR5, and Fab Fragment From A DR5 Agonist Antibody, PDB code: 4n90:

Zinc binding site 1 out of 1 in the Crystal Structure of Ternary Complex of Trail, DR5, and Fab Fragment From A DR5 Agonist Antibody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Ternary Complex of Trail, DR5, and Fab Fragment From A DR5 Agonist Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:56.4 occ:1.00 SG A:CYS230 2.2 41.1 1.0 SG B:CYS230 2.2 34.2 1.0 SG C:CYS230 2.3 33.7 1.0 CB B:CYS230 3.0 43.5 1.0 CB A:CYS230 3.1 43.8 1.0 CB C:CYS230 3.1 36.2 1.0 CA A:CYS230 3.4 44.0 1.0 CA C:CYS230 3.5 37.2 1.0 CA B:CYS230 3.6 45.8 1.0 N A:TRP231 4.2 51.8 1.0 N B:TRP231 4.2 46.8 1.0 N C:TRP231 4.3 40.9 1.0 C A:CYS230 4.3 46.0 1.0 C B:CYS230 4.4 45.6 1.0 C C:CYS230 4.4 39.1 1.0 N A:CYS230 4.6 41.9 1.0 N C:CYS230 4.6 37.5 1.0 N B:CYS230 4.8 47.1 1.0

J.D.Graves, J.J.Kordich, T.H.Huang, J.Piasecki, T.L.Bush, T.Sullivan, I.N.Foltz, W.Chang, H.Douangpanya, T.Dang, J.W.O'neill, R.Mallari, X.Zhao, D.G.Branstetter, J.M.Rossi, A.M.Long, X.Huang, P.M.Holland. APO2L/Trail and the Death Receptor 5 Agonist Antibody Amg 655 Cooperate to Promote Receptor Clustering and Antitumor Activity. Cancer Cell V. 26 177 2014.
ISSN: ISSN 1535-6108
PubMed: 25043603
DOI: 10.1016/J.CCR.2014.04.028