Zinc in PDB 4n3w: Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC).

Enzymatic activity of Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC).

All present enzymatic activity of Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC).:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC)., PDB code: 4n3w was solved by A.N.Plotnikov, S.Yang, M.-M.Zhou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.58 / 1.90
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 92.460, 59.312, 53.444, 90.00, 102.96, 90.00
R / Rfree (%) 23.3 / 28.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC). (pdb code 4n3w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC)., PDB code: 4n3w:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4n3w

Go back to Zinc Binding Sites List in 4n3w
Zinc binding site 1 out of 2 in the Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC). within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1401

b:36.4
occ:1.00
 ND1 A:HIS1291 1.9 32.5 1.0
SG A:CYS1200 2.3 36.6 1.0
SG A:CYS1199 2.4 37.7 1.0
SG A:CYS1294 2.4 35.7 1.0
CE1 A:HIS1291 2.8 34.4 1.0
CG A:HIS1291 3.0 36.1 1.0
CB A:CYS1199 3.3 40.4 1.0
CB A:CYS1294 3.4 36.8 1.0
CB A:CYS1200 3.5 33.9 1.0
CB A:HIS1291 3.5 36.5 1.0
N A:CYS1200 3.6 35.9 1.0
NE2 A:HIS1291 3.9 31.9 1.0
C A:CYS1199 3.9 41.3 1.0
CA A:CYS1200 4.0 35.7 1.0
CD2 A:HIS1291 4.1 33.4 1.0
CA A:CYS1199 4.2 39.2 1.0
N A:HIS1291 4.2 33.3 1.0
O A:HOH1547 4.3 45.2 1.0
C A:CYS1200 4.4 32.3 1.0
O A:CYS1199 4.5 37.6 1.0
CA A:HIS1291 4.5 36.4 1.0
O A:CYS1200 4.5 34.2 1.0
CA A:CYS1294 4.8 33.5 1.0
O A:HOH1580 4.8 48.2 1.0
N A:CYS1199 4.9 42.4 1.0
NH2 A:ARG1202 4.9 50.0 1.0

Zinc binding site 2 out of 2 in 4n3w

Go back to Zinc Binding Sites List in 4n3w
Zinc binding site 2 out of 2 in the Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC).


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Bromodomain-Phd Finger Module of Human Transcriptional Co-Activator Cbp in Complex with Acetylated Histone 4 Peptide (H4K20AC). within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1402

b:47.7
occ:1.00
 SG A:CYS1311 2.3 50.0 1.0
SG A:CYS1283 2.3 47.2 1.0
SG A:CYS1308 2.4 54.6 1.0
SG A:CYS1286 2.4 44.2 1.0
CB A:CYS1311 3.2 63.0 1.0
CB A:CYS1283 3.2 42.7 1.0
CB A:CYS1286 3.3 46.2 1.0
CB A:CYS1308 3.5 54.4 1.0
N A:CYS1286 3.7 43.2 1.0
N A:CYS1308 4.0 53.4 1.0
CA A:CYS1286 4.0 46.9 1.0
O A:ASN1310 4.1 0.7 1.0
CA A:CYS1308 4.2 55.8 1.0
O A:CYS1308 4.5 61.2 1.0
CA A:CYS1311 4.6 66.4 1.0
CA A:CYS1283 4.6 48.0 1.0
CB A:GLU1285 4.6 49.3 1.0
C A:CYS1308 4.7 58.5 1.0
C A:GLU1285 4.8 55.1 1.0
O A:HOH1609 4.8 46.0 1.0
C A:CYS1286 4.9 43.0 1.0
NH1 A:ARG1288 4.9 43.5 1.0

Reference:

A.N.Plotnikov, S.Yang, T.J.Zhou, E.Rusinova, A.Frasca, M.M.Zhou. Structural Insights Into Acetylated-Histone H4 Recognition By the Bromodomain-Phd Finger Module of Human Transcriptional Coactivator Cbp. Structure V. 22 353 2014.
ISSN: ISSN 0969-2126
PubMed: 24361270
DOI: 10.1016/J.STR.2013.10.021
Page generated: Sun Oct 27 02:59:50 2024

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