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Zinc in PDB 4kxa: Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium

Enzymatic activity of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium

All present enzymatic activity of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium:
3.4.11.7;

Protein crystallography data

The structure of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium, PDB code: 4kxa was solved by Y.Yang, C.Liu, Y.Y.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.57 / 2.40
Space group P 64 2 2
Cell size a, b, c (Å), α, β, γ (°) 142.093, 142.093, 237.414, 90.00, 90.00, 120.00
R / Rfree (%) 15.2 / 22.4

Other elements in 4kxa:

The structure of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium (pdb code 4kxa). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium, PDB code: 4kxa:

Zinc binding site 1 out of 1 in 4kxa

Go back to Zinc Binding Sites List in 4kxa
Zinc binding site 1 out of 1 in the Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Aminopeptidase A Complexed with Aspartate and Calcium within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1002

b:0.8
occ:1.00
 OE1 A:GLU416 2.0 62.2 1.0
NE2 A:HIS397 2.3 60.8 1.0
NE2 A:HIS393 2.4 54.1 1.0
CD A:GLU416 2.9 66.8 1.0
OXT A:ASP1019 3.0 0.8 1.0
CD2 A:HIS397 3.2 57.9 1.0
CD2 A:HIS393 3.2 53.9 1.0
OE2 A:GLU416 3.2 74.5 1.0
CE1 A:HIS397 3.3 61.1 1.0
CE1 A:HIS393 3.4 54.9 1.0
OH A:TYR479 3.7 71.8 1.0
CE2 A:TYR479 3.9 53.5 1.0
N A:ASP1019 3.9 91.7 1.0
C A:ASP1019 4.0 0.3 1.0
OE1 A:GLU360 4.1 78.0 1.0
CZ A:TYR479 4.2 58.0 1.0
CG A:HIS397 4.3 58.0 1.0
ND1 A:HIS397 4.3 61.5 1.0
CG A:GLU416 4.3 67.5 1.0
CG A:HIS393 4.4 53.7 1.0
CB A:ALA419 4.4 56.6 1.0
ND1 A:HIS393 4.5 54.9 1.0
CA A:ASP1019 4.6 99.4 1.0
CD A:GLU360 4.6 71.0 1.0
OE2 A:GLU394 4.7 66.0 1.0
CA A:GLU416 4.7 58.6 1.0
OE2 A:GLU360 4.7 70.8 1.0
CB A:GLU416 4.7 59.5 1.0
O A:HOH1270 4.9 66.7 1.0
O A:ASP1019 4.9 0.1 1.0
CD2 A:TYR479 4.9 51.5 1.0

Reference:

Y.Yang, C.Liu, Y.L.Lin, F.Li. Structural Insights Into Central Hypertension Regulation By Human Aminopeptidase A. J.Biol.Chem. V. 288 25638 2013.
ISSN: ISSN 0021-9258
PubMed: 23888046
DOI: 10.1074/JBC.M113.494955
Page generated: Sun Oct 27 01:24:54 2024

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